Publications by authors named "Y Tojima"
Introduction: spp. are a public health concern, yet there is still no effective vaccine or medicine available.
Methods: Here, we developed a -specific antibody and found that it targeted a menaquinol cytochrome reductase complex QcrC.
Background: Single-agent chemotherapy with or without bevacizumab (Bev) is a standard therapy for platinum-resistant ovarian cancer (PR-OC). However, there is a lack of literature on chemotherapy agent selection in heterogenous PR-OC. Therefore, we aimed to clarify the heterogeneous treatment effects of each chemotherapy agent.
View Article and Find Full Text PDFPurpose: Pegylated liposomal doxorubicin (PLD)-induced hand-foot syndrome (HFS) frequently lowers the quality of life of ovarian cancer patients. Wrist and ankle cooling, having a limited preventive effect, has been the commonest supportive HFS care. In this study, we retrospectively assessed the primary preventive effect of a combination of regional cooling and oral dexamethasone therapy (cooling + oral Dex) on HFS.
View Article and Find Full Text PDFBackground: and Shiga toxin (Stx)-producing (STEC) are common causes of food poisoning. We previously demonstrated the efficacy of Stx2B-C-CPE, a fusion protein of the C-terminal region of enterotoxin (C-CPE) and Shiga toxin 2 B subunit (Stx2B), as a bivalent vaccine against and STEC infections.
Methods: Here, we applied an expression system and Triton X-114 phase separation to prepare tag- and endotoxin-free Stx2B-C-CPE for use in vaccine formulations.
Article Synopsis
- The study focuses on the gut microbiome's role in diseases, particularly highlighting the Blautia genus, especially B. wexlerae, as beneficial bacteria linked to lower obesity and type 2 diabetes rates in Japanese adults.
- Administering B. wexlerae to mice led to positive metabolic changes and reduced inflammation, which helped combat obesity and diabetes caused by high-fat diets.
- The beneficial effects of B. wexlerae stem from its unique amino-acid and carbohydrate metabolism, suggesting potential new ways to prevent and treat metabolic disorders through gut microbiome regulation.