Publications by authors named "Y Toh"
Objectives: To investigate the incidence, laryngeal distribution, management, and postoperative clinical course of patients with newly diagnosed adult-onset recurrent respiratory papillomatosis (RRP) in Japan.
Methods: An initial brief questionnaire was sent to 782 institutions, including all 101 core and 627 collaborating institutions providing board certification programs accredited by the Japanese Society of Otorhinolaryngology-Head and Neck Surgery. A detailed questionnaire regarding patient age, sex, Derkay's score, surgery, and postoperative clinical course was sent to 196 institutions caring for patients with either newly or previously diagnosed RRP.
Article Synopsis
- - The study investigates how splenic vein occlusion (SpVO) from pancreatic tumors affects surgical outcomes and complications in patients undergoing distal pancreatectomy (DP).
- - Out of 124 patients analyzed, 20.8% had SpVO, leading to longer surgery times and more postoperative complications compared to those with open splenic veins.
- - The findings suggest that understanding collateral circulation patterns can aid in better surgical planning to minimize complications related to left-sided portal hypertension caused by SpVO.
Article Synopsis
- Antibody-drug conjugates (ADCs) are a promising targeted cancer treatment, but none have been approved specifically for colorectal cancer (CRC) yet.
- LGR4/5/6 receptors are commonly found in CRC, and while ADCs targeting LGR5 show strong anti-tumor effects, not all CRC cells express LGR5, leading to challenges.
- A new drug conjugate, R462-CPT2, combines a modified RSPO4 protein with a potent drug and has displayed effective anti-tumor activity in CRC models without significant side effects, making it a strong candidate for CRC therapy.