Publications by authors named "Y Tijani"

Echis ocellatus is one of the commonest snakes responsible for envenomation in Nigeria. Antivenom is the only effective treatment, but the country suffers from a limited supply of effective antivenom. This study therefore aimed to explore the feasibility of effective, mono-specific antibodies production through immunization in rabbits using the venom of Echis ocellatus from Nigeria.

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Introduction: Hypertension is the leading cause of death in the cardiovascular system. Indeed, untreated hypertension can affect one's general health, but medicine can help hypertensive people reduce their chance of developing high blood pressure. However, secondary hypertension remains an unresolved illness.

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Hypertension is the major risk factor for cardiovascular morbidity and mortality. Matter of fact, untreated hypertension can worsen the overall health, whereas pharmacotherapy can play an important role in lowering the risk of high blood pressure in hypertensive patients. However, persistent uncontrolled hypertension remains an unsolved condition characterized by non-adherence to medication and increased sympathetic activity.

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Article Synopsis
  • Butyrylcholinesterase (BChE) plays a crucial role in the progression of Alzheimer's disease, as its normal function is disrupted in patients with advanced AD, impacting cholinergic neurotransmission.
  • Research utilized enzyme kinetic studies, molecular modeling, and protein-ligand interactions to investigate how methylrosmarinate interacts with BChE, revealing that it binds effectively in BChE's active site and stabilizes interactions with various subsites.
  • The study found that methylrosmarinate significantly inhibits BChE, with specific kinetic values indicating it could be a promising inhibitor, although the exact mechanisms of this inhibition in relation to various disease conditions need further research.
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