Publications by authors named "Y Tarumoto"
Article Synopsis
- The study identifies specific host factors, such as TRIM28, TRIM33, EHMT1, and EHMT2, that are crucial for SARS-CoV-2 infection by using CRISPR-Cas9 screening.
- TRIM28 may help with the formation of viral particles, while TRIM33, EHMT1, and EHMT2 are likely involved in the virus's transcription and replication processes.
- The compound UNC0642, which inhibits the activity of EHMT1/2, demonstrated significant potential in reducing SARS-CoV-2 growth and disease severity in test models.
Sugarcane (Saccharum spp.) plays a crucial role in global sugar production; however, the efficiency of breeding programs has been hindered by its heterozygous polyploid genomes. Considering non-additive genetic effects is essential in genome prediction (GP) models of crops with highly heterozygous polyploid genomes.
View Article and Find Full Text PDFSugarcane ( spp. hybrids) and its processed products have supported local industries such as those in the Nansei Islands, Japan. To improve the sugarcane quality and productivity, breeders select better clones by evaluating agronomic characteristics, such as commercially recoverable sugar and cane yield.
View Article and Find Full Text PDFArticle Synopsis
- Single-cell RNA sequencing combined with CRISPR allows researchers to understand gene regulation, but single snapshots can miss long-term effects of gene knockouts.
- RENGE is a new computational method that analyzes time-series data from single-cell CRISPR experiments to model how gene knockouts impact regulatory networks over time.
- By distinguishing between direct and indirect gene regulations, RENGE provides more accurate insights into gene interactions, which can help identify important factors in biological systems.
Acute leukemia cells require bone marrow microenvironments, known as niches, which provide leukemic cells with niche factors that are essential for leukemic cell survival and/or proliferation. However, it remains unclear how the dynamics of the leukemic cell-niche interaction are regulated. Using a genome-wide CRISPR screen, we discovered that canonical BRG1/BRM-associated factor (cBAF), a variant of the switch/sucrose nonfermenting chromatin remodeling complex, regulates the migratory response of human T-cell acute lymphoblastic leukemia (T-ALL) cells to a niche factor CXCL12.
View Article and Find Full Text PDF