Prediction of slaughter weight with body components and liner body measurement of cattle at Haramaya University abattoir, Ethiopia.

The aim of the study was to determine the relationship between slaughter weight (SW) with body components and liner body measurements and investigate the coefficient of correlation between slaughter weight with body component and liner body measurements to select the best regression equation. Data on liner body measurements (height at wither and at hips, heart girth, body length, height and width of hump, height at fall and hind legs, body sheath height, height at hooks, barrel circumference, width of face, length of face and tail circumference) and slaughter weight of body components (Hot Carcass Weight (HCW), Empty Body Weight (ESW), Internal Offal (IO) and External Offal (EO)) were collected from 62 Hararghe cattle at Haramaya University abattoir. ESW was calculated as SW with less gut contents.

In silico prediction of some pharmacokinetic, safety, biological activity and molecular docking studies of 1-piperazine indole hybrid with nicotinic amide and nicotinic acid and their analogues.

Background: In silico predictions are now being utilized in drug discovery and design to assess the physicochemical, pharmacokinetics, and safety properties of compounds at the beginning of the drug discovery process. This early evaluation of the physicochemical, pharmacokinetics, and safety properties of compounds helps the researchers to invest their time and resources only in the best prospective lead compounds by eliminating compounds with a low chance of success.

Objective: The purpose of this study was to explore a promising lead compound designed from 1-piperazine indole hybrid with nicotinic amide and nicotinic acid analogs targeted on phosphofructokinase for Trypanosomiasis activity by using in silico predictions strategy.

Economic values of some important traits for smallholder dairy production in Central Ethiopia.

Economic value (EV), sensitivity of EV and relative economic importance of milk yield (MY), age at first calving (AFC), calving interval (CI) and herd life (HL) traits were estimated for smallholder dairy cattle production in the central part of Ethiopia. The data on biological and economic parameters were collected using household interview and group discussions methods participating 238 farmers who had crossbred dairy cattle. Bio-economic model was used to calculate EV, sensitivity of EV and relative importance of EV.

Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells.

Hair cells of the inner ear and lateral-line system rely on specialized ribbon synapses to transmit sensory information to the central nervous system. The molecules required to assemble these synapses are not fully understood. We show that Nrxn3, a presynaptic adhesion molecule, is crucial for ribbon-synapse maturation in hair cells.