Instrumental analysis of trace elements in thumbnails of human subjects.

Human thumbnails were analyzed for trace elements by instrumental analysis using thermal neutron activation technique. The average concentration of metals studied in clinically symptom-free adult female and male subjects were: zinc, 184 vs. 153 ppm; chromium, 6.

Selected sulfhydryl inhibitors capable of inducing immunity against cancer in mice.

Selected sulfhydryl inhibitors show greater toxicity to some animal and human cancers than to normal cells, both clinically and in drug sensitivity tests. Such selected SH inhibitors can induce immunity against cancer in mice, unlike other commonly used antitumor agents. Scanning electron micrographs of the surface of Ehrlich ascites cancer cells treated with the sulfhydryl inhibitors show blunting to absence of microvilli and modification of the surface texture of the cancer cells.

Effect of temperature on binding of warfarin by human serum albumin.

The in vitro binding of warfarin by human serum albumin was studied at various temperatures and at pH 7.4 by a frontal gel filtration technique. The results can be best described in terms of a two class-of-binding site model, in which the numbers of primary and secondary sites are constrained to the average values for all experiments (n1 = 1.