[Effect of osteon-like concentric microgroove structures of different sizes on the osteoclastic differentiation of macrophages].

To investigate the effect of the sizes of osteon-like concentric microgroove structures on the osteoclastic differentiation of macrophages on titanium surfaces, and to provide reference for the surface modification of implants. The silicon wafers sputtered with titanium were selected as the control group (smooth surface specimens) and four concentric groups (concentric circles with the maximum diameter of 200 μ m, the minimum diameter of 20 μ m, the spacing of concentric circles of 10 or 30 μm, the width of microgrooves of 10 or 30 μm, and the depth of microgrooves of 5 or 10 μm) specimens (the total sample size in each group was 27). The width of microgrooves of C10-5 and C10-10 groups was 10 μm, the depth was 5 and 10 μm, and the width of microgrooves of C30-5 and C30-10 groups was 30 μ m, the depth was 5 and 10 μ m, respectively.

Correction: Self-generating electricity system driven by aqueous humor flow and trabecular meshwork contraction motion activated BKCa for glaucoma intraocular pressure treatment.

Correction for 'Self-generating electricity system driven by aqueous humor flow and trabecular meshwork contraction motion activated BKCa for glaucoma intraocular pressure treatment' by Ruiqi Wang , , 2025, https://doi.org/10.1039/D4MH01004C.

[Analysis of factors influencing quality of life in patients with olfaction disorders].

To explore the differences in quality of life among patients with olfaction disorders (OD) due to various etiologies and to identify factors influencing olfactory-related quality of life. This cross-sectional study enrolled patients with OD who visited the Department of Otolaryngology at Fudan University Eye, Ear, Nose, and Throat Hospital between February and June 2024. Psychophysical olfactory test was performed using the Chinese Smell Identification Test (CSIT), which was based on the Chinese population, with the TDI score used as the total score for threshold (T), discrimination (D), and identification (I) tests.

Aspergixanthones L-T, nine undescribed prenylxanthone derivatives from Aspergillus stellatus.

Nine undescribed prenylxanthone derivatives, aspergixanthones L-T (1-9), were isolated from the fungus Aspergillus stellatus. Compound 4 represents the first propionylated prenylxanthone, while compounds 7-9 are the first examples of prenylxanthones adorned with a 2,3-butanediol group. Their structures with absolute configurations were elucidated based on comprehensive spectroscopic analyses, ECD calculation, single-crystal X-ray diffraction, Mo(OAc) induced ECD experiment, and Mosher's method.

Network pharmacology alliance with experimental validation unveils the anti-colorectal cancer mechanism of Xianlian Jiedu Decoction.

Ethnopharmacological Relevance: The Xianlian Jiedu Decoction (XLJDD), a traditional Chinese medicine (TCM) decoction, which is effective in clinical treatment of colorectal cancer (CRC). Nevertheless, the pharmacodynamic material basis and mechanism of its action have not been explored yet.

Aims Of The Study: To investigate the potential functional components and possible mechanism of XLJDD in anti-CRC.