Vascular remodeling and association with inflammation in the heart of obesity model.

Introduction: Obesity alters several metabolic activities, subsequently leading to the development of cardiovascular diseases. The insulin resistance-induced obesity stimulates vasodilatation and vasoconstriction imbalance, which ends up in cardiac vascular remodeling. Therefore, we aimed to investigate the effect of obesity in cardiac diseases with a focus on inflammatory mediators associated with endothelial dysfunction.