Publications by authors named "Y Stein"
Objective: The objective of this study was to investigate whether trigeminal somatosensory function and mechanosensitivity differ between groups with craniofacial neuropathic pain (CNP), non-neuropathic craniofacial pain (NNP), and healthy controls (HC).
Methods: Thirty-three participants were categorized into these groups, matched for age and sex. The study evaluated pain intensity, the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), and various trigeminal somatosensory tests, including vibration, pressure pain, thermal detection, cold pain, and neurodynamic tests of the trigeminal nerve.
Article Synopsis
- The RAS genes are key oncogenes frequently mutated in cancer, and their deregulation leads to tumorigenesis, making them critical targets for drug design.
- The study uses molecular dynamics simulations to examine how different mutations affect the structural properties and binding interactions of RAS isoforms, revealing important insights into their oncogenic behaviors.
- Findings suggest that manipulating isoform interactions can provide a novel therapeutic strategy for RAS-driven cancers, leading to the development of specific inhibitory drugs targeting these mutations.
Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.
Am J Respir Crit Care Med
August 2024
Changes in peripheral blood cell populations have been observed, but not detailed, at single-cell resolution in idiopathic pulmonary fibrosis (IPF). We sought to provide an atlas of the changes in the peripheral immune system in stable and progressive IPF. Peripheral blood mononuclear cells (PBMCs) from patients with IPF and control subjects were profiled using 10× chromium 5' single-cell RNA sequencing.
View Article and Find Full Text PDFThe tumor microenvironment (TME) is comprised of non-malignant cells that interact with each other and with cancer cells, critically impacting cancer biology. The TME is complex, and understanding it requires simplifying approaches. Here we provide an experimental-mathematical approach to decompose the TME into small circuits of interacting cell types.
View Article and Find Full Text PDFRationale: Changes in peripheral blood cell populations have been observed but not detailed at single-cell resolution in idiopathic pulmonary fibrosis (IPF).
Objectives: To provide an atlas of the changes in the peripheral immune system in stable and progressive IPF.
Methods: Peripheral blood mononuclear cells (PBMCs) from IPF patients and controls were profiled using 10x Chromium 5' single-cell RNA sequencing (scRNA-seq).