New Atg9 Phosphorylation Sites Regulate Autophagic Trafficking in Glia.

We previously identified a role for dAuxilin (dAux), the fly homolog of Cyclin G-associated kinase, in glial autophagy contributing to Parkinson's disease (PD). To further dissect the mechanism, we present evidence here that lack of glial dAux enhanced the phosphorylation of the autophagy-related protein Atg9 at two newly identified threonine residues, T62 and T69. The enhanced Atg9 phosphorylation in the absence of dAux promotes autophagosome formation and Atg9 trafficking to the autophagosomes in glia.

Bis(dialkylaminethiocarbonyl)disulfides Act as Electron Acceptors for EDA Complexes for the Synthesis of Dithiocarbamate Derivatives under Visible Light.

This study proposes a green and efficient atom- and step-economical method for converting hazardous CS to dithiocarbamate derivatives under visible light irradiation and catalyst-free conditions. By the construction of novel C-S and C-N bonds, a series of β-dicarbonyl compounds and amines are incorporated into the products. Under light, CS and amine first form bis(dialkylaminethiocarbonyl)disulfides, which then react with KCO-activated β-dicarbonyl compounds to form electron donor-acceptor (EDA) complexes and subsequently generate the target products.

Zinc Chloride-Doped g-CN Microtubes for Enhanced Photocatalytic Degradation of Tetracycline Hydrochloride.

Morphology regulation and element doping are effective means to improving the photocatalytic performance of graphite-phase carbon nitride (g-CN). In this article, using melamine and zinc chloride as raw materials, a novel kind of Zn/Cl-doped hollow microtubular g-CN (Zn-HT-CN) by a hydrothermal method was developed. The structure and morphology of Zn-HT-CN and reference samples were characterized by X-ray diffraction patterns (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), etc.

Adiponectin facilitates the cell cycle, inhibits cell apoptosis and induces temozolomide resistance in glioblastoma via the Akt/mTOR pathway.

Adiponectin (ADN) regulates DNA synthesis, cell apoptosis and cell cycle to participate in the pathology and progression of glioblastoma. The present study aimed to further explore the effect of ADN on temozolomide (TMZ) resistance in glioblastoma and the underlying mechanism of action. Glioblastoma cell lines (U251 and U87-MG cells) were treated with ADN and TMZ at different concentrations; subsequently, 3.