Publications by authors named "Y Someya"
Sulforaphane (SFN), an isothiocyanate found in plants of the Brassicaceae family, possesses antioxidant, apoptosis-inducing, and radiosensitizing effects. As one of the mechanisms of cytotoxicity by SFN, SFN has been suggested to be involved in the induction of DNA damage and inhibition of DNA repair. Recently, we reported on the potency of SFN in inducing single-ended double-strand breaks (DSBs) that are caused by the collision of replication forks with single-strand breaks (SSBs).
View Article and Find Full Text PDFArticle Synopsis
- The study explores the impact of exercise habits from adolescence to old age on the risk of developing geriatric depression among older adults.
- It involved 1,629 participants aged 65-84 and categorized them based on their exercise practices into four distinct groups.
- Results show that individuals who exercised at any point in their life, particularly in adolescence and old age, had significantly lower levels of depressive symptoms compared to those who never exercised.
Background: Cerebral small-vessel disease (cSVD), a key risk factor for stroke and dementia, has been linked to obesity and low bone mineral density (BMD). While obesity and low BMD are often inversely related, their coexistence may increase cSVD risk. We aimed to assess the prevalence of obesity and low BMD coexistence and its association with increased cSVD prevalence.
View Article and Find Full Text PDFBackground: Exercise in adolescence and old age improves cognitive function in older adults, but the combined effect of exercise habits in both periods is controversial. This study aimed to clarify the relationship between exercise habits in adolescence and old age and mild cognitive impairment (MCI) and to compare regional brain volumes and blood biochemical markers associated with cognitive function in older adults.
Methods: Baseline data of 1615 participants aged 65-84 years from the Bunkyo Health Study were analyzed.
Quercetin exhibits cytotoxicity in cancer cells by inducing two-ended DNA double-strand breaks.
Biochem Biophys Res Commun
December 2024
Article Synopsis
- Quercetin, a flavonoid with antioxidant properties, can induce DNA double-strand breaks (DSBs) in a concentration-dependent manner, but the exact mechanism behind this effect is still unclear.
- The study used HeLa cells and gene-knockout cell lines to investigate that quercetin does not primarily involve DNA topoisomerase II (Top2) in inducing DSBs; instead, a transient accumulation of reactive oxygen species (ROS) is linked to this process.
- The DSBs caused by quercetin are mainly repaired through non-homologous end-joining and homologous recombination, suggesting it could be used as a radiomimetic agent with effects similar to X-ray exposure.