Publications by authors named "Y Sio"
Background: Metabolic surgery is recognized for its effectiveness in weight loss and improving outcomes for individuals with type 2 diabetes mellitus (T2DM). However, its impact on renal function, especially in multi-ethnic Asian populations, remains underexplored. This study investigates mid- and long-term renal outcomes following metabolic surgery in Asian patients with T2DM.
View Article and Find Full Text PDFArticle Synopsis
- Allergic rhinitis (AR) affects a significant percentage (35.4%) of Chinese young adults in Singapore, presenting mainly with symptoms like rhinorrhea and nasal pruritus.
- The study categorized AR cases into different severity classes, revealing that 68.1% have moderate to severe symptoms, with many experiencing troubling symptoms and sleep disturbances.
- A staggering 85.2% of AR cases remain undiagnosed, 72.5% untreated, and 65.4% experience both, indicating a critical need for better management and awareness of AR in this population.
Introduction: FOXO1 plays an important role in regulating immune processes that contribute to allergic inflammation; however, genetic variants influencing FOXO1 expression in AR pathogenesis remains unclear. This study aimed to investigate the functional effect of FOXO1 single nucleotide polymorphisms (SNPs) on AR development by performing genetic association and functional analysis studies.
Methods: This study belongs to a part of an ongoing Singapore/Malaysia cross-sectional genetics and epidemiological study (SMCSGES).
Background: Atopic dermatitis (AD) is a complex inflammatory disease with a strong genetic component. A singular approach of genome wide association studies (GWAS) can identify AD-associated genetic variants, but is unable to explain their functional relevance in AD. This study aims to characterize AD-associated genetic variants and elucidate the mechanisms leading to AD through a multi-omics approach.
View Article and Find Full Text PDFBackground And Objective: Sleep disruption has been shown to affect immune function and thus influence allergic disease manifestation. The specific effects of sleep on allergic diseases, however, are less well-established; hence, in a unique population of young Chinese adults, we investigated the association between sleep and allergic disease.
Methods: Young Chinese adults recruited from Singapore in the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) were analyzed.