DCLRE1B as a novel prognostic biomarker associated with immune infiltration: a pancancer analysis.

The DNA cross-link repair 1B (DCLRE1B) gene is involved in repairing cross-links between DNA strands, including those associated with Hoyeraal-Hreidarsson syndrome and congenital dyskeratosis. However, its role in tumours is not well understood. DCLRE1B expression profiles were examined in tumour tissues and normal tissues using TCGA, GTEx, and TARGET datasets.

An updated network meta-analysis of non-pharmacological interventions for primary hypertension in adults: insights from recent studies.

Background: Primary hypertension significantly impacts global cardiovascular health, contributing to increased mortality rates and posing a substantial public health challenge. Recognizing the growing evidence supporting non-pharmacological interventions (NPIs) for controlling primary hypertension, our study employs Network Meta-Analysis (NMA) to comprehensively assess their efficacy.

Methods: This review updates a prior systematic review by searching for original literature on NPIs for primary hypertension from 2013 to 2024.

Prognostic value of combined systemic inflammation response index and prognostic nutritional index in colorectal cancer patients.

Background: The prognosis of colorectal cancer (CRC) patients is notably influenced by both inflammation and nutritional status. The prognostic nutritional index (PNI) and systemic inflammatory response index (SIRI) have been reported in prognostic studies of various tumors. However, the efficacy of the combination of the two in predicting the prognosis of CRC patients has not been studied.

A small molecule modified UiO series MOFs for simultaneous detection of Fe and Zn.

Iron and zinc are two metal ions with important roles in biology, industry and the environment, however, the excess or deficiency of both Fe and Zn can have negative effects on organisms and environment. Therefore, the development of efficient method for simultaneous detection of Fe and Zn provides timely information on metal content, simplifies operations and improves efficiency. In this work, a small molecule (COOH-BPEA) of recognizing Zn modified the four metal-organic-framework (MOF) (UiO-66-X(66, OH, NH and OH/NH)) was developed for the simultaneous detection of Fe and Zn.

Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCN neurons.

Dexmedetomidine (DexM), a highly selective α-adrenoceptor agonist, significantly reduces postoperative adverse effects, including sleep and circadian rhythm disruptions. Vasoactive intestinal peptide neurons in the suprachiasmatic nucleus (SCN) regulate the synchronization of circadian rhythms with the external environment in mammals. We investigate the effects of DexM on sleep and circadian rhythms, as well as the underlying mechanisms.