Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway.

Postpartum depression (PPD) adversely affects the growth and development of the offspring, increasing the risk of various internalizing behaviorsduring adolescence. Studies have shown that corticosterone (CORT)-induced PPD affects neurogenesis in the offspring, which is closely related to the onset of depression. However, the underlying mechanisms of these changes in the offspring of PPD mothers remain unexplored.

Three new species of (Amphisphaeriales, Apiosporaceae) in China.

China is located in eastern Asia and has a large quantity and rich variety of bamboo resources. Bamboo resources also contain various fungal species such as The genus is commonly used as plant pathogens, endophytes, and saprophytes, which are widely present in various host ranges around the world. The discovery of metabolites has been proven to play an important role in the pharmaceutical industry.

Phylogeny and taxonomy of (Polyporales, Basidiomycota) with four new species from Asia and Oceania.

(Berk.) Murrill, first described from North America, was considered to be a common species in China. The existence of a species complex is confirmed through a phylogenetic analysis of samples examined.

A computational chemistry-based approach to optimizing PD-1/PD-L1 inhibitors.

Introduction: To design effective small molecule inhibitors targeting the immune checkpoint PD-1/PD-L1 and to explore their inhibitory activity.

Methods: In this paper, a total of 69 PD-1/PD-L1 inhibitors with the same backbone were searched through opendatabases, and their docking mechanism with PD-L1 protein was investigatedby molecular docking method, and the active conformation of the inhibitors was explored. The biological activity of the four newly designed inhibitors was also evaluated using ELISA.

Corrigendum: Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis of randomized controlled trials.

[This corrects the article DOI: 10.3389/fonc.2024.