Publications by authors named "Y Sekido"
Inactivation of the Hippo tumor suppressive pathway is frequently observed in mesothelioma, which leads to the activation of YAP and TAZ (YAP/TAZ) transcriptional coactivators. YAP/TAZ form complexes with TEAD family members, DNA-binding proteins, to activate transcription, which promotes cancer cell growth and proliferation. Recently developed TEAD inhibitors exhibit antitumor activity by inhibiting the formation of the transcription complex through binding to TEAD; however, the antitumor activity of TEAD inhibitors against mesothelioma remains to be fully elucidated.
View Article and Find Full Text PDFInflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), predominantly affects young patients and leads to intestinal complications. Amyloidosis, which involves abnormal protein deposition, is a serious complication of IBD, with a low incidence. Early detection of subclinical amyloid deposits is crucial for preventing fatal outcomes; however, routine investigations are lacking.
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- - The study investigates the effectiveness of loop-end ileostomy (EI), introduced in 2021, in reducing stoma outlet obstruction (SOO) in patients undergoing restorative proctocolectomy (RPC) and ileal pouch-anal anastomosis (IPAA), compared to traditional loop ileostomy (LI).
- - Researchers analyzed 106 patients with diverting ileostomy, finding that EI significantly lowered the incidence of SOO (odds ratio 0.18) despite similar patient characteristics and surgery factors between the two groups.
- - The conclusion suggests that EI is a promising approach to minimize SOO complications following RPC and IPAA, particularly in more complex anastomosis cases.
Article Synopsis
- Sarcopenia, the loss of muscle mass with age, negatively impacts prognosis in gastrointestinal cancer, particularly when combined with visceral obesity, known as sarcopenic obesity.
- A study involving 211 colorectal cancer patients revealed that those with sarcopenic obesity had significantly shorter cancer-related relapse-free survival (CRRFS) compared to those without obesity.
- Key predictors of poor CRRFS included sarcopenic obesity, high levels of carcinoembryonic antigen, and unfavorable cancer histology, suggesting that improving muscle mass and reducing visceral fat could enhance patient outcomes.
Background: The short-term outcomes of chemoradiotherapy (CRT) with S-1 (a combination of tegafur, gimeracil, and oteracil) following limited surgery for patients with T1 or T2 lower rectal cancer have shown encouraging results.
Objectives: This study was designed to delve deeper into the long-term outcomes of CRT with S-1 after limited surgery, with the goal of evaluating both the long-term efficacy and potential risks associated with this treatment approach in patients diagnosed with T1 or T2 lower rectal cancer.
Methods: This was conducted as a multicenter, single-arm, prospective phase II trial.