Publications by authors named "Y Seiki"
Objectives: Endoscopic ultrasonography (EUS) plays an important role in the diagnosis of pancreatobiliary diseases. However, an appropriate sedation method for EUS has not been established. Therefore, this study aimed to examine the safety and complications of sedation with pentazocine or pethidine hydrochloride for outpatient diagnostic EUS.
View Article and Find Full Text PDFAntiapoptotic protein, including Mcl-1, expression is frequently observed in pancreatic cancer. Gemcitabine plus nabpaclitaxel (GnP) is the standard chemotherapy for metastatic pancreatic cancer (MPC); however, predictive markers for its efficacy remain unestablished. This study evaluated the association between GnP's therapeutic effects and Mcl-1 expression in tissue samples obtained using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic tumor or percutaneous ultrasound-guided biopsy for metastatic liver tumor.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the detection of gBRCA mutations in pancreatic cancer patients and the effectiveness of olaparib maintenance therapy for those mutations.
- Out of 84 patients tested, 11.9% had gBRCA mutations, with a higher mutation rate found in individuals with a family history of Hereditary Breast and Ovarian Cancer (HBOC).
- Most patients who received olaparib after platinum-based chemotherapy showed positive responses, with a median treatment duration of 17.5 months for chemotherapy and 11 months for olaparib maintenance therapy.
Article Synopsis
- Patients with advanced pancreatic cancer often suffer from taste disturbances (dysgeusia) and zinc deficiency during chemotherapy, prompting a study on the effects of zinc supplementation.
- A study involving 33 patients evaluated the impact of zinc acetate hydrate over 12 weeks, finding significant increases in serum zinc levels and gradual improvement in taste issues—a 42.4% improvement by the end of the study.
- The results suggest that zinc supplementation not only enhances taste perception but may also help maintain nutritional status, as evidenced by stable serum albumin levels in patients who responded to treatment.
Article Synopsis
- Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is important for diagnosing pancreatic cancer and initiating targeted therapies, but sample insufficiency is a common issue that needs to be addressed.
- A study conducted at the Osaka International Cancer Institute involved 42 patients, comparing the effectiveness of oil blotting paper versus filter paper for fixing EUS-TA samples for analysis.
- Results showed that samples fixed with oil blotting paper had significantly larger tissue areas and a higher frequency of abundant tumor cells, suggesting it enhances sample adequacy for molecular testing.