Publications by authors named "Y Salazar"
Malaria represents a challenging global public health task, with being the predominant parasite in Brazil and the most widely distributed species throughout the world. Developing a vaccine against malaria demands innovative strategies, and targeting gametocyte antigens shows promise for blocking transmission prevention. Among these antigens, Pvs47, expressed in gametocytes, has shown remarkable efficacy in transmission blocking.
View Article and Find Full Text PDFObjectives: Primaquine is essential for the radical cure of Plasmodium vivax malaria and must be metabolized into its bioactive metabolites. Accordingly, polymorphisms in primaquine-metabolizing enzymes can impact the treatment efficacy. This pioneering study explores the influence of monoamine oxidase-A (MAO-A) on primaquine metabolism and its impact on malaria relapses.
View Article and Find Full Text PDFArticle Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
Article Synopsis
- Primaquine (PQ) is the primary medication used to eliminate dormant malaria stages and prevent relapses, though its effect on malaria gametocytes remains unclear.
- Genetic variations in the CYP2D6 and cytochrome P450 reductase (CPR) enzymes can influence PQ metabolism, so a study was conducted on 100 malaria patients to assess these effects on gametocyte activity.
- Results indicated that individuals with specific genetic mutations had a smaller reduction in gametocyte levels after treatment, suggesting that pharmacogenetics plays a significant role in malaria transmission potential during the initial treatment period.
Objective: To highlight the objectives, achievements, challenges, and next steps for the World Health Organization's Global Initiative for Childhood Cancer (GICC) framework, a project designed to improve psychosocial care (PSC) in pediatric cancer centers across Latin America and the Caribbean (LAC).
Methods: The project was launched in Peru, the first GICC focal country, in November 2020. The diagnosis phase included a survey and a semistructured interview with health professionals to assess PSC practices in institutions, and a needs assessment survey for caregivers.