Publications by authors named "Y Sakamaki"
Objective: This study aimed to elucidate the therapeutic significance of lung resection for primary lung cancer after pancreatic cancer surgery in contemporary cases.
Methods: This retrospective cohort study included patients who had lung nodules and performed pulmonary resection after pancreatic cancer surgery at seven hospitals affiliated with the Thoracic Surgery Study Group of Osaka University between January 2009 and December 2021. Patients in which surgery was performed for biopsy purposes, those with a history of other cancers with potential for lung metastasis, patients who did not give their consent for enrollment, and patients determined to be ineligible by the attending physician were excluded from the study.
Article Synopsis
- Exposure to N-methyl-N-nitrosourea (MNU) in rats disrupts neurogenesis in the hippocampus and triggers changes in gene expression across various brain regions.* -
- Analysis revealed that MNU administration led to increased expression of genes associated with immune and inflammatory responses, as well as apoptosis regulation, particularly at the highest dosage of 15 mg/kg.* -
- Immunohistochemical findings indicated that MNU treatment elevated markers for neuroinflammation and oxidative stress, highlighting a dual response in the brain involving both damage and protective mechanisms through activated microglia.*
Fluoride affects neurodevelopment in children. In this study, we examined the effects of developmental exposure to sodium fluoride (NaF) on hippocampal neurogenesis in rats. Dams were given drinking water containing NaF at 0 (untreated controls), 30 or 100 ppm from gestational day 6 to day 21 post-delivery upon weaning, and offspring were reared until postnatal day (PND) 77.
View Article and Find Full Text PDFThe environmental contaminant perchlorate raises concern for hypothyroidism-related brain disorders in children. This study investigated the effects of developmental perchlorate exposure on hippocampal neurogenesis and oligodendrocyte (OL) development. Pregnant Sprague-Dawley rats were administered with ammonium perchlorate (AP) in drinking water at concentrations of 0 (control), 300, and 1000 ppm from gestation day 6 until weaning [postnatal day (PND) 21].
View Article and Find Full Text PDFArticle Synopsis
- Lipid membranes were created using DNA tethers that were attached to pyrene for functionalization and self-assembly with phospholipids, which resulted in uniform membranes verified by fluorescence microscopy.
- High-energy X-ray reflectivity measured the membranes before and after hybridization, revealing that the tilting of DNA spacers was less than expected, indicating flexibility rather than a stiff upright structure.
- Atomic force microscopy (AFM) showed that membranes with DNA tethers had higher resistance to compression compared to those without, while the unchanged yield depth implies that dsDNA can flexibly adjust its position due to the pliable pyrene-DNA connections.