Publications by authors named "Y Saba"
Article Synopsis
- - RANKL is identified as a key player in periodontitis, primarily influencing osteoclast differentiation and acting as a link between bone and the immune system, showcasing a complex role beyond its initial recognition as an activator of dendritic cells (DCs).
- - In studies using ligature-induced periodontitis (LIP), rapid bone loss was observed, which eventually stopped despite the presence of the ligature, indicating a connection to immunosuppressive conditions in the gingiva associated with T regulatory (Treg) cell expansion.
- - Experiments with K14-RANKL mice, which overexpress RANKL in gingival cells, revealed that increased RANKL leads to a favorable balance of immune cells
Article Synopsis
- Spinal muscular atrophy (SMA) is a serious genetic disorder with limited treatment options, and its prevalence needs more research in Arab countries due to high rates of consanguinity.* -
- A study involved diagnosing SMA in 171 patients and newborn screenings in 1,502 Emirati infants, revealing a carrier frequency of 1.3% and an incidence of 1 in 7,122 live births for the disease in the UAE.* -
- Results indicate that implementing premarital genetic screening could significantly reduce SMA cases and save healthcare costs, highlighting the need for wider screening practices in Arab populations.*
The postnatal interaction between microbiota and the immune system establishes lifelong homeostasis at mucosal epithelial barriers, however, the barrier-specific physiological activities that drive the equilibrium are hardly known. During weaning, the oral epithelium, which is monitored by Langerhans cells (LC), is challenged by the development of a microbial plaque and the initiation of masticatory forces capable of damaging the epithelium. Here we show that microbial colonization following birth facilitates the differentiation of oral LCs, setting the stage for the weaning period, in which adaptive immunity develops.
View Article and Find Full Text PDFBackground: Continuous glucose monitoring (CGM) devices improve clinical outcomes and facilitate achieving patient-specific goals. However, opportunities and barriers to implementation of pharmacist-driven CGM services are not well-described.
Objectives: This scoping review was conducted to identify opportunities and barriers to implementing pharmacist-driven CGM services in the community and ambulatory care setting.
The American Diabetes Association's emphasize the need for awareness regarding overbasalization (basal insulin doses >0.5 units/kg/day without bolus insulin) in the treatment of type 2 diabetes. However, outcomes data on the impact of overbasalization are limited.
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