Publications by authors named "Y S Yau"
Article Synopsis
- Mitochondrial trifunctional protein deficiency is a disorder affecting long-chain fatty acid metabolism, leading to severe heart issues like cardiomyopathy and arrhythmias.
- Triheptanoin, a synthetic medium-chain triglyceride, has shown potential to improve cardiomyopathy in some cases, although research is limited for severe presentations.
- A case is presented of a newborn with severe disease who did not improve despite receiving mechanical support and triheptanoin treatment.
Article Synopsis
- Restorative neurostimulation of the lumbar multifidus muscle shows promise as a treatment option for chronic low back pain (CLBP) in patients who have previously undergone lumbar surgery, a group often excluded from studies.
- In a case series of 26 patients, significant improvements were observed in low back pain scores and disability indices over 12 months, with 40% achieving clinically important improvements.
- Patient satisfaction rates were high, and there were minimal adverse events, indicating that this therapy may be safe and effective for those with prior lumbar surgery.
Over the course of the COVID-19 pandemic, variants have emerged with increased mutations and immune evasive capabilities. This has led to breakthrough infections (BTI) in vaccinated individuals, with a large proportion of the neutralizing antibody response targeting the receptor binding domain (RBD) of the SARS-CoV-2 Spike glycoprotein. Immune imprinting, where prior exposure of the immune system to an antigen can influence the response to subsequent exposures, and its role in a population with heterogenous exposure histories has important implications in future vaccine design.
View Article and Find Full Text PDFBackground: Dementia, particularly Alzheimer's disease, is a major healthcare challenge in ageing societies.
Objective: This study aimed to investigate the efficacy and safety of a dietary compound, ergothioneine, in delaying cognitive decline in older individuals.
Methods: Nineteen subjects aged 60 or above with mild cognitive impairment were recruited for this double-blinded, randomized, and placebo-controlled study (ClinicalTrials.
Patients with head and neck cancers often require radiotherapy, where immobilization devices like thermoplastic masks ensure precise radiation delivery by minimizing movement. However, the quality of these masks lacks standard reference data. This study aimed to establish institutional acceptance criteria for thermoplastic mask quality and quantify their effectiveness using a 3 dimensional stress test and verified the setup errors using daily megavoltage computed tomography (MVCT).
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