Mechanisms of multidrug resistance caused by an Ipi1 mutation in the fungal pathogen Candida glabrata.

Multidrug resistance in the pathogenic fungus Candida glabrata is a growing global threat. Here, we study mechanisms of multidrug resistance in this pathogen. Exposure of C.

Factors Related to Blood Loss During Endoscopic Sinus Surgery.

Background: The safety and efficacy of endoscopic sinus surgery have improved with the development of new equipment and improved surgical techniques. However, it is accompanied by the risk of complications. Intraoperative blood loss is an important factor in the safe conduct of surgery.

Factors associated with physical activity in patients with upper gastrointestinal cancer during outpatient chemotherapy: A cross-sectional study.

Objective: This study aimed to clarify the physical activity level of patients with upper gastrointestinal cancer during outpatient chemotherapy and the factors associated with decreased physical activity levels after drug administration.

Methods: In this cross-sectional study, activity intensity and steps were measured using an accelerometer in 39 patients with upper gastrointestinal cancer for 1 week before and after drug administration. Furthermore, the participants responded to a questionnaire on their lifestyles.

Segment-specific promoter activity for RNA synthesis in the genome of Oz virus, genus Thogotovirus.

Oz virus (OZV), a tick-borne, six-segmented negative-strand RNA virus in the genus Thogotovirus, caused a fatal human infection in Japan in 2023. To study viral RNA synthesis, we developed an OZV minigenome assay using mammalian cells. This revealed variations in promoter activities among the six genome segments.

Estimating the paths and mechanical behaviors of the plantar aponeurosis during dynamic movements using a multiple-marker foot model incorporating anatomically-detailed plantar aponeurosis morphology.

Background: Several foot models have been developed to estimate the behaviors of the plantar aponeurosis (PA) during movements. However, these models did not consider the actual path of the PA, and their validity remains insufficiently investigated due to the absence of direct PA measurement during movements.

Research Question: Would developing a foot model that considers the actual path of the PA improve the accuracy of estimating the PA behavior during movements?

Methods: The foot model was developed based on the CT scans of the six feet with 20 markers attached.