Control of Electrolyte Desolvation Energy Suppressing the Cointercalation Mechanism and Organic Electrode Dissolution.

Despite numerous studies aimed at solving the detrimental dissolution issue of organic electrode materials (OEMs), a fundamental understanding of their dissolution mechanism has not yet been established. Herein, we systematically investigate how changes in electrolyte composition affect the ion-solvent interactions propagating to OEM dissolution by changing the cation. The cyclability of OEM is significantly different by alkali cations, where the OEM with K is stable even after 300 cycles and that with Li is drastically decayed within 100 cycles.

In Situ Programmable, Active, and Interactive Crystallization by Localized Polymerization.

Additive manufacturing has sought active and interactive means of creating predictable structures with diverse materials. Compared to such active manufacturing tools, current crystallization strategies remain in statistical and passive programs of crystals via macroscale thermodynamic controllers, commonly lacking active means to intervene in crystal growth in a spatiotemporal manner. Herein, a strategy toward active and interactive programming and reprogramming of crystals, realized by real-time tangible feedback on growing crystals by delicately controlling the degree of in-situ, localized photopolymerization of polymeric structures via additive manufacturing is presented.

Dual-Mechanism mRNA Delivery via Fluorinated-Sorbitol Polyplexes: Enhancing Cellular Uptake and Endosomal Escape for COVID-19 Vaccination.

Advancements in mRNA delivery nanoparticles have significantly improved the potential for treating challenging diseases. Due to the inherent immunogenicity and rapid degradation of mRNA, specialized nanoparticles are required for efficient intracellular uptake, endosomal escape, and protection from lysosomal degradation. Although current methods enable transgene expression but achieving a balance between efficiency and toxicity remains challenging.

Epidemiology, timing, technique, and outcomes of tracheostomy in patients with trauma: a multi-centre retrospective study.

Background: Tracheostomy is performed in patients with trauma who need prolonged ventilation for respiratory failure or airway management. Although it has benefits, such as reduced sedation and easier care, it also has risks. This study explored the unclear timing, technique, and patient selection criteria for tracheostomy in patients with trauma.

Effectiveness and Safety of Polydioxanone Thread Embedding Acupuncture Compared with Acupuncture Treatment for Knee Osteoarthritis: a Protocol for a Pilot, Assessor-Blinded, Randomized Controlled Trial.

Importance: Knee osteoarthritis (OA) is a common degenerative joint disease in aging populations. Knee OA is difficult to cure and requires ongoing management. Thread embedding acupuncture (TEA) is a popular Korean medical treatment for knee OA.