Publications by authors named "Y S Kanwar"
Article Synopsis
- The study examined the prevalence of metabolic syndrome (MS) and chronic kidney disease (CKD) among 3,212 adults in Ningbo, China, highlighting their association with low socioeconomic status (SES).
- The results showed that 9.1% of participants had CKD, with MS affecting 23.1%, and individuals with MS had significantly higher odds (2.43 times) of developing CKD.
- Key findings also indicated that factors like age, female gender, and low SES contributed to the increased risk of CKD and albuminuria in the study population.
Article Synopsis
- CHIP (Carboxy-terminus of Hsc70-interacting protein) is an E3 ligase that helps regulate protein stability and plays a crucial role in reducing damage from acute kidney injury (AKI), especially related to cisplatin treatment.
- In cisplatin-induced AKI, CHIP levels decrease, leading to increased oxidative stress and cell death in renal proximal tubular cells.
- The study shows that CHIP promotes the degradation of NUR77, a protein that contributes to apoptosis, thus suggesting a protective mechanism against kidney damage caused by cisplatin.
Cisplatin-induced acute kidney injury (AKI) is commonly seen in the clinical practice, and ferroptosis, a type of non-apoptotic cell death, plays a pivotal role in it. Previous studies suggested that protein arginine methyltransferase 4 (PRMT4) was incorporated in various bioprocesses, but its role in renal injuries has not been investigated. Our present study showed that PRMT4 was highly expressed in renal proximal tubular cells, and it was downregulated in cisplatin-induced AKI.
View Article and Find Full Text PDFSeptic acute kidney injury (S-AKI), the most common type of acute kidney injury (AKI), is intimately related to pyroptosis and oxidative stress in its pathogenesis. Carboxy-terminus of Hsc70-interacting protein (CHIP), a U-box E3 ligase, modulates oxidative stress by degrading its targeted proteins. The role of CHIP in S-AKI and its relevance with pyroptosis have not been investigated.
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