Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD.

Autism spectrum disorder (ASD) is linked to ion channel dysfunction, including chloride voltage-gated channel-4 (CLCN4). We generated Clcn4 knockout (KO) mice by deleting exon 5 of chromosome 7 in the C57BL/6 mice. Clcn4 KO exhibited reduced social interaction and increased repetitive behaviors assessed using three-chamber and marble burying tests.

Analysis of Reproductive Strategies and Immunological Interactions in -Resistant Japanese Tree Frogs.

The amphibian chytrid fungus, (), has been implicated as an agent of acute declines in amphibian populations worldwide. East Asian amphibians have been coexisting with for long periods and thus are considered resistant; among the many is the Japanese tree frog, . Our study focused infection effects on reproductive behaviors and physiological parameters in as a function of better understanding the chronic effect of the disease on long-term population viability.

Preference for Distinct Variants in Learning Sound Correspondences During Dialect Acquisition.

Sound correspondences (SCs) have been found to be learnable phonological patterns in second dialect acquisition. Cross-linguistically, SCs consist of similar as well as distinct variants. However, in the study of SC learning, the effect of the similarity between the corresponding variants remains understudied.

Reduced-intensity chemotherapy with tyrosine kinase inhibitor followed by allogeneic transplantation is effective in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

Background/aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retrospective study compared treatment outcomes and induction mortality according to backbone regimen intensity.

Methods: The data of 132 patients diagnosed with Ph-positive ALL were retrospectively collected from five centers. Patients received imatinib plus intensive chemotherapy (modified VPD, KALLA1407, or hyper-CVAD) or reduced-intensity chemotherapy (EWALL) for curative purposes.

The characteristics of Korean elderly multiple myeloma patients aged 80 years or over.

Background/aims: Multiple myeloma (MM) predominantly affects elderly individuals, but studies on older patients with MM are limited. The clinical characteristics and survival outcomes of patients with MM aged 80 years or over were retrospectively analyzed.

Methods: This retrospective multicenter study was conducted to investigate the clinical characteristics, treatment patterns, and survival outcomes of patients aged 80 years or over who were newly diagnosed with MM at five academic hospitals in Daegu, Korea, between 2010 and 2019.