Publications by authors named "Y S Davidson"
Mov Disord Clin Pract
August 2024
Article Synopsis
- Corticobasal syndrome is usually linked to common conditions like corticobasal degeneration and Alzheimer's, but this case highlights a rare cause.
- A 78-year-old woman initially diagnosed with idiopathic Parkinson's disease developed symptoms that led to a revised diagnosis of probable corticobasal syndrome after an MRI showed specific brain atrophy.
- After her death, post-mortem findings confirmed Pick's disease, demonstrating that it can mimic corticobasal syndrome symptoms, which is important for differential diagnosis.
J Alzheimers Dis
April 2024
Article Synopsis
- - The study aimed to explore the relationship between late-life hypertension and Alzheimer's disease (AD) pathology, focusing on individuals over 65 and the effects of antihypertensive medication.
- - Researchers used self-reported hypertension data and brain assessments from 108 deceased participants, discovering that those with hypertension had lower levels of AD pathology despite no significant cognitive impairment.
- - The findings imply that late-life hypertension may actually correlate with milder AD pathology, potentially due to factors like reduced blood flow affecting the brain.
Brain Pathol
September 2024
Article Synopsis
- FFPE brain tissue in tissue banks is a valuable resource for research, especially with clinical data and psychological testing available.
- APOE genotyping is crucial for understanding this tissue, but older FFPE samples may not provide reliable results.
- The study found that DNA from FFPE brain tissue stored for more than three years may degrade, affecting APOE genotyping effectiveness.
J Alzheimers Dis
January 2022
Article Synopsis
- Early diagnosis of Alzheimer's disease (AD) through cognitive testing can lead to early intervention, and the Telephone Assessment for Cognitive Screening (TICS) is effective in screening for cognitive impairment, though its ability to signal future AD risk is still being explored.
- The study investigates the relationship between TICS scores collected over 13 years and the cognitive status of participants at death, alongside their neuropathological indices of AD.
- Results show that lower TICS scores correlate with cognitive impairment and AD pathology in participants, suggesting that TICS could be a useful tool for identifying those at risk of developing AD long before symptoms appear, potentially allowing for early intervention strategies.
