Bladder outlet procedures without augmentation cystoplasty: Long-term outcomes and association of preoperative bladder compliance with subsequent augmentation cystoplasty or urinary diversion and DMSA abnormalities.

Background: A bladder outlet procedure (BOP) without augmentation cystoplasty (AC) for incontinence from neurogenic bladder has risks including renal damage and future surgeries.

Objective: Our objective was to obtain long-term outcomes after BOP without AC and identify risk factors for adverse outcomes. We hypothesized that high preoperative bladder compliance is associated with lower risk of subsequent AC or diversion (AC/D) and dimercaptosuccinic acid renal scan (DMSA) abnormalities.

Ambulatory status and sexual function and activity in young adults with spina bifida.

Introduction: Young adults with spina bifida may experience altered genital sensation and sexual function. There are no validated questionnaires and few studies examining sexual function and activity in this population. Ambulatory status has previously been associated with better erectile function, but few studies report on other domains of sexual function in men and women.

A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines.

The human genome contains instructions to transcribe more than 200,000 RNAs. However, many RNA transcripts are generated from the same gene, resulting in alternative isoforms that are highly similar and that remain difficult to quantify. To evaluate the ability to study RNA transcript expression, we profiled seven human cell lines with five different RNA-sequencing protocols, including short-read cDNA, Nanopore long-read direct RNA, amplification-free direct cDNA and PCR-amplified cDNA sequencing, and PacBio IsoSeq, with multiple spike-in controls, and additional transcriptome-wide N-methyladenosine profiling data.

Tailoring Versatile Nanoheterojunction-Incorporated Hydrogel Dressing for Wound Bacterial Biofilm Infection Theranostics.

Wound-infected bacterial biofilms are protected by self-secreted extracellular polymer substances (EPS), which can confer them with formidable resistance to the host's immune responses and antibiotics, and thus delays in diagnosis and treatment can cause stubborn infections and life-threatening complications. However, tailoring an integrated theranostic platform with the capability to promptly diagnose and treat wound biofilm infection still remains a challenge. Herein, a versatile erbium-doped carbon dot-encapsulated zeolitic imidazolate framework-8 (Er:CDs@ZIF-8) nanoheterojunction (C@Z nano-HJ) is tailored and incorporated into gelatin methacrylate/poly(-hydroxyethyl acrylamide) (GelMA/PHEAA)-based tough and sticky hydrogel dressing (GH-C@Z) to achieve wound biofilm infection-integrated theranostic application.

Innovative Design and Synthesis of Fullerene-Terpyridine Derivatives for Enhanced Electron Transport in Inverted Perovskite Solar Cells.

In this study, three fullerene derivatives─, , and ─were synthesized and investigated as additives in PCBM-based electron-transporting layers (ETLs) for inverted perovskite solar cells (PVSCs). The incorporation of and into the ETLs led to improved ETL morphology and passivation of crystal defects on the surface of the methylammonium lead iodide (MAPbI) layer. This defect passivation enhanced crystal quality, increased UV-vis absorption, reduced charge recombination, and improved electron mobility in the - and -based PVSCs.