Strong segregation promotes self-destructive cooperation.

Self-destructive cooperators, which sacrifice themselves for others, challenge traditional group selection theory, as costs often exceed individual benefits. We predict self-destructive cooperators can persist in highly segregated environments where populations are primarily divided into homogenous groups originating from one or two founders. In such contexts, the benefits of self-destructive cooperators remain within homogeneous groups of self-destructive cooperators, preserving the sacrifice value and ensuring its maintenance.

Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin.

Background: Gestational diabetes mellitus (GDM) affects up to 14% of pregnancies globally, with insulin resistance (IR) playing a critical but often underappreciated role in its pathogenesis. Yet the specific impact of insulin at IR levels on mitochondrial function and pyroptosis in first-trimester trophoblasts remains unclear. Metformin use in GDM pregnancies is rising, but its impact on placental mitochondrial function is uncertain.

Few-shot traffic classification based on autoencoder and deep graph convolutional networks.

Traffic classification is a crucial technique in network management that aims to identify and manage data packets to optimize network efficiency, ensure quality of service, enhance network security, and implement policy management. As graph convolutional networks (GCNs) take into account not only the features of the data itself, but also the relationships among sets of data during classification. Many researchers have proposed their own traffic classification methods based on GCN in recent years.

CKMT1 deficiency contributes to mitochondrial dysfunction and promotes intestinal epithelial cell apoptosis via reverse electron transfer-derived ROS in colitis.

Mitochondrial dysfunction contributes to the pathogenesis of ulcerative colitis (UC). As a mitochondrial isozyme of creatine kinases, which control energy metabolism, CKMT1 is thought to be a critical molecule in biological processes. However, the specific role of CKMT1 in intestinal inflammation remains largely unknown.