Publications by authors named "Y Roh"
Rolling circle amplification (RCA)-derived ultra-long DNA is highly attractive and versatile because of its diverse functionalities conferred by repeated DNA nanostructures. However, magnesium pyrophosphate (MgPPi) crystals, as byproducts of RCA, electrostatically interact with the DNA to form DNA microhybrids and hamper its broad bioapplications, as its large size is unfavorable for cellular uptake and decreases the density of functional DNA nanostructures. In this study, finely tuned synthesis strategies are developed to condense the microhybrids and replace non-functional MgPPi crystals with various functional metal nanostructures by reducing metal ions.
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- This study focused on how the adenosine A3 receptor (A3AR) influences the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) through the regulation of immune cells, particularly pro-inflammatory Kupffer cells derived from monocytes (MoKCs).
- Researchers found that inhibiting A3AR, either through a drug called FM101 or by genetic deletion, significantly improved liver inflammation and fibrosis in model mice.
- The results suggest that targeting A3AR may offer a novel therapeutic approach for treating MASLD by inducing cell death (necroptosis) in harmful immune cells, thereby promoting a healthier liver environment.
Objective: Popliteal artery entrapment syndrome (PAES) results from an anomalous relationship between the popliteal artery and the myofascial structures of the popliteal fossa. The long-term treatment outcomes are not well known because of the rarity of the disease. This study aimed to establish a nationwide collective dataset, and analyze treatment outcomes.
View Article and Find Full Text PDFObjective: This study aimed to compare the accuracy of brain biopsies in skull-brain tumor models (SBTMs) of dogs and cats using 2 techniques: 3-D-printed brain biopsy guides (3D-BBGs) and electromagnetic (EM) neuronavigation.
Methods: Based on the CT data from 12 dogs and 3 cats, a total of 30 SBTMs were created using 3-D-printing technology, with 2 models per data set. Thirty brain biopsies were performed: 15 using 3D-BBGs and 15 using EM neuronavigation.
Article Synopsis
- The study focuses on detecting multijet signatures from proton-proton collisions at a high energy of 13 TeV, analyzing a dataset totaling 128 fb^{-1}.
- A special data scouting method is utilized to pick out events with low combined momentum in jets.
- This research is pioneering in its investigation of electroweak particle production in R-parity violating supersymmetric models, particularly examining hadronically decaying mass-degenerate higgsinos, and it broadens the limits on the existence of R-parity violating top squarks and gluinos.