Publications by authors named "Y Ramanathan"
Background: Accurate estimates of incremental cost (IC) attributable to antimicrobial resistance (AMR) provide information of immense public health importance to the policy makers. Here, we present the IC from patient perspective for treating antimicrobial-resistant pathogens in India.
Methods: This cohort study was conducted in eight hospitals including government (GH), private (PH) and trust hospitals (TH), considering their ownership, geographical location and categories of cities.
Article Synopsis
- The study investigates the prevalence and impact of candidaemia in 67 ICUs across India, assessing how the COVID-19 pandemic influenced its rates and mortality.* -
- Data from 401,601 patient days revealed higher candidaemia rates in COVID-19 ICUs (2.52/1000 patient days) compared to non-COVID-19 ICUs (1.05/1000 patient days), with associated mortality significantly higher in COVID-19 cases (61% vs. 41%).* -
- Analysis identified C. tropicalis as the most common isolated species (26.7%), while C. auris, which had a high mortality rate, accounted for 17.5% of isolates
Background: The availability of rapid diagnostic platforms for positive blood cultures has accelerated the speed at which the clinical microbiology laboratory can identify the causative organism and facilitate early appropriate antimicrobial therapy. There is a paucity of data regarding the clinical utility of the blood culture identification 2 (BCID2) panel test and its correlation with phenotypic drug susceptibility testing (DST) in flagged blood culture bottles from intensive care units (ICUs) in countries such as India, which have high rates of multidrug-resistant gram-negative bacteria (MDR-GNB).
Materials And Methods: We conducted a retrospective observational study in a tertiary care ICU on 200 patients above 18 years of age in whom a BCID2 test was ordered when blood cultures flagged positive.
Improving Antimicrobial Resistance Awareness Among Medical Students in India: The Sensitization of Medical Students on Antimicrobial Resistance (SOS-AMR) Study.
J Med Educ Curric Dev
March 2024
Objectives: To evaluate the impact of an online educational intervention on improving knowledge of antimicrobial resistance (AMR) and stewardship among final-year medical students in Chennai, India.
Methods: This was a prospective 'before-after' study conducted across 5 medical colleges in Chennai, India. Participants who were final-year (fourth year) undergraduate medical students were administered a pretest to evaluate baseline knowledge.
A Pilot Feasibility Randomized Controlled Trial of Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit: The Lessening Organ Dysfunction with Vitamin C-India (LOVIT-India) Trial.
Indian J Crit Care Med
December 2023
Background: The burden of sepsis is high in India and is associated with substantial morbidity and mortality. Vitamin C, an endogenous antioxidant, may improve patient outcomes.
Methods: This was a parallel-group pilot feasibility randomized controlled trial conducted at 2 intensive care units in India.