[Recovery from ischemic stroke at a young age].

Ischemic stroke at a young age has serious physiological and psychological consequences for patients; it is associated with a wide range of etiopathogenetic factors, whose detection can prevent the recurrence of events. This requires a better understanding of these etiopathogenetic factors, the mechanisms of their manifestation and individual risks. Cognitive impairment is often a consequence of stroke that is especially sensitive for young patients.

[CHANGE IN BCL-2 PROTEIN EXPRESSION IN NEURONS OF THE HIPPOCAMPAL AREAS AFTER THE APPLICATION OF ISCHEMIC CEREBRAL POSTCONDITIONING].

Bcl-2 protein expression was studied in hippocampal CA1, CA2, CA3 and CA4 pyramidal neurons in Mongolian gerbils (Meriones unguiculatus), of the in in the early (Day 2) and late (Day 7) reperfusion period after a 7-minute forebrain ischemia and following ischemic postconditioning (IPostC), as well as in sham-operated animals (n=60). In the latter, the highest level, of Bcl-2-expression was found in CA4 neurons, while the lowest--in-CA1 neurons (P<0.01).

[Morpho-functional changes of the pyramidal neurons in various hippocampal areas after the ischemic postconditioning].

The aim of this study was to determine the effect of ischemic postconditioning (IP) on the viability of neurons in various hippocampal areas as well as on cytoplasmic activity of succinatedehydrogenase (SDH) in these cells in 30 male Mongolian gerbils (Meriones unguiculatus). Ischemic brain injury was induced by bilateral common carotid artery occlusion for 7 min. IP protocol comprised 3 cycles of 15 s of reperfusion/15 s of ischemia.