Genome-wide association study unravels mechanisms of brain glymphatic activity.

Brain glymphatic activity, as indicated by diffusion-tensor imaging analysis along the perivascular space (ALPS) index, is involved in developmental neuropsychiatric and neurodegenerative diseases, but its genetic architecture is poorly understood. Here, we identified 17 unique genome-wide significant loci and 161 candidate genes linked to the ALPS-indexes in a discovery sample of 31,021 individuals from the UK Biobank. Seven loci were replicated in two independent datasets.

TERTp Mutation and its Prognostic Value in Glioma Patients Under the 2021 WHO Classification: A Real-World Study.

Background: The 2021 WHO Classification of Central Nervous System Tumors introduces more molecular markers for glioma reclassification, including TERT promoter (TERTp) mutation as a key feature in glioblastoma diagnosis.

Aims: Given the changes in the entities included in each subtype under the new classification, this research investigated the distribution, prognostic value, and correlations with other molecular alterations of TERTp mutation in different subgroups under this latest classification.

Methods: All glioma patients admitted to Peking Union Medical College Hospital for surgical resection or biopsy from 2011 to 2022 were included.

Synthesis, structures, and optical properties of N-heterocycle and amino acid ester-coordinated BH.

A series of N-Het·BH and AAE·BH complexes were prepared in moderate to high yields and the single-crystal structures of products 3, 31, 34, and 59 were determined. The N-Het·BH and AAE·BH complexes possess high stability, endowing these products with potential applications in luminescent and boron-containing drugs. The optical properties of the representative products have been preliminarily studied.

What is the optimal display range? Exploring the impacts of area and shape on in-vehicle head-up display efficiency.

In-vehicle Head-Up Displays (HUDs) are expected to incorporate more information in the future, necessitating deeper understandings of design properties that can enhance display safety and efficiency. However, the optimal display characteristics-particularly in terms of area and shape-remain inadequately understood. This study investigated these two factors by manipulating horizontal and vertical Field of View (FOV) angles within a simulated in-vehicle HUD.