Efficacy and safety of a T-type calcium channel blocker in patients with neuropathic pain: A proof-of-concept, randomized, double-blind and controlled trial.

Background: T-type calcium channels have been shown to play an important role in the initiation and maintenance of neuropathic pain and represent a promising therapeutic target for new analgesic treatments. Ethosuximide (ETX), an anticonvulsant and a T-type channel blocker has shown analgesic effect in several chronic pain models but has not yet been evaluated in patients with neuropathic pain.

Methods: This proof-of-concept, multicentre, double-blind, controlled and randomized trial compared the efficacy and safety of ETX (given as add-on therapy) to an inactive control (IC) in 114 patients with non-diabetic peripheral neuropathic pain.

Eustachian valve mimicking a right atrial cystic tumor.

We report the case of a 65-year-old patient referred to our hospital for stroke. In the course of the diagnostic procedure, a transesophageal echocardiography was performed and showed at first sight a mass attached to the right aspect of the interatrial septum and mimicking a cystic tumor. But after performing multiple views, it was in fact demonstrated a large Eustachian valve with its extremity attached to the right aspect of the interatrial septum.