Publications by authors named "Y Patt"
Crohn's disease (CD) and Ankylosing Spondylitis (AS) are chronic conditions with overlapping inflammatory pathways. This research investigates the genetic association between AS and the requirement for more aggressive therapeutic interventions in CD, suggesting a likelihood of increased severity in CD progression among individuals diagnosed with AS. This study utilized two-sample Mendelian randomization (TSMR) to analyze GWAS datasets for AS and CD requiring second-line treatment.
View Article and Find Full Text PDFSarcoidosis is a multisystem granulomatous disorder with a variable clinical course and complications. The relationship between sarcoidosis and malignancies remains unclear, including specific malignancy associations with sarcoidosis and whether the association is short-term, long-term, or a result of misdiagnoses or coincidence. This study investigated the association between sarcoidosis and malignancy by analyzing the varying intervals between the diagnoses of these two conditions to clarify their inter-relationship.
View Article and Find Full Text PDFArticle Synopsis
- Sarcoidosis is a condition that causes chronic inflammation and the formation of granulomas, which can lead to varying outcomes; some patients have mild issues while others face severe complications and higher mortality risk.
- A retrospective cohort study analyzed data from Clalit Health Services to compare mortality rates between sarcoidosis patients and matched controls, revealing a significantly higher mortality rate (17.7% vs. 10.6%).
- The study found that younger patients (under 50) experienced the highest mortality risk shortly after diagnosis, with age, male gender, and higher comorbidity scores being key predictors of increased mortality.
Background: The best first-line monotherapy for hypertension remains uncertain, as current guidelines suggest that thiazides, angiotensin-converting enzyme inhibitors (ACEis), angiotensin receptor blockers (ARBs), and calcium channel blockers (CCBs) are appropriate in the absence of specific comorbidities. We aimed to compare the outcomes of first-line antihypertensive classes in a real-life setting with a long follow-up period.
Methods: This nationwide retrospective new-user cohort study included patients insured by the largest health maintenance organization in Israel.
Article Synopsis
- The study aimed to evaluate the risk of seizures in patients with Giant Cell Arteritis (GCA) compared to matched controls in Israel.
- A total of 8,103 GCA patients and 32,412 controls were analyzed, showing that GCA patients had a higher incidence of seizures (15.92 cases per 10,000 person-years) than controls (9.62 per 10,000).
- The findings indicate that GCA patients have a significantly increased risk of seizures, which is likely related to the inflammatory state associated with GCA, rather than pre-existing conditions like stroke.