Significant unfavorable geometrical changes in ascending aorta despite stable diameter at follow-up.

Objective: The clinical importance of following up on the ascending aortic diameter lies in the fundamental presumption that wall pathology eventually manifests as a change in shape. However, the diameter describes the vessel locally, and the 55 mm criterion fails to prevent most dissections. We hypothesized that geometric changes across the ascending aorta are not necessarily imprinted on its diameter; i.

An adaptive semi-implicit finite element solver for brain cancer progression modeling.

Glioblastoma is the most aggressive and infiltrative glioma, classified as Grade IV, with the poorest survival rate among patients. Accurate and rigorously tested mechanistic in silico modeling offers great value to understand and quantify the progression of primary brain tumors. This paper presents a continuum-based finite element framework that is built on high performance computing, open-source libraries to simulate glioblastoma progression.

Automated ascending aorta delineation from ECG-gated computed tomography images.

The instrumental role of comprehensive geometrical quantification in contemporary, effective descriptions of aortic growth and disease is well established. General or specific purpose algorithms are being developed to provide automatic landmark detection and high accuracy measurements. In the present study, an objective method for automated delineation of the ascending aorta is introduced, based on geometrical properties of the aortic wall.

Combined effect of shear stress and laser-patterned topography on Schwann cell outgrowth: synergistic or antagonistic?

Although the peripheral nervous system exhibits a higher rate of regeneration than that of the central nervous system through a spontaneous regeneration after injury, the functional recovery is fairly infrequent and misdirected. Thus, the development of successful methods to guide neuronal outgrowth, in vitro, is of great importance. In this study, a precise flow controlled microfluidic system with specific custom-designed chambers, incorporating laser-microstructured polyethylene terephthalate (PET) substrates comprising microgrooves, was fabricated to assess the combined effect of shear stress and topography on Schwann cells' behavior.

Spatial Distribution of Abdominal Aortic Aneurysm Surface Expansion and Correlation With Maximum Diameter and Volume Growth.

Background: Abdominal aortic aneurysm (AAA) growth rate, measured as maximum diameter (Dmax) change over time, is used as a surrogate marker of rupture risk. However, AAA expansion presents significant spatial variability. We aim to record the spatial distribution of regional wall surface expansion.