Renal Function as a Predictor of Mortality and Functional Outcomes in Acute Stroke: A Prospective Study.

Background: Stroke is a leading cause of global morbidity and mortality, and understanding modifiable predictors of stroke outcomes is crucial. This study explores the relationship between renal function, assessed via estimated glomerular filtration rate (eGFR) and serum creatinine, and stroke mortality and functional outcomes in a cohort of acute stroke patients in India.

Methods: A prospective observational study was conducted from February 2021 to October 2022, including 104 acute stroke patients from MS Ramaiah Medical College and Hospital, Bengaluru, India.

Navigating cancer therapy: Harnessing the power of peptide-drug conjugates as precision delivery vehicles.

Cancer treatment is a formidable challenge due to the adverse effects associated with non-selective therapies like chemotherapy and radiotherapy. This review article primarily centers on the application of Peptide-Drug Conjugates (PDCs) for delivering cancer treatment. PDCs represent a promising class of precision medicines, harnessing the unique attributes of peptides in conjunction with non-peptide components.

Effect of supplementation of distillers' dried grain with solubles (DDGS) to a straw-based diet on performance, carcass characteristics, and meat quality in Nellore ram lambs.

Distillers dried grains with solubles (DDGS), a byproduct of ethanol production, has gained recognition as a viable alternative feed supplement for ram lambs because of its nutritional profile and cost-effectiveness. This study evaluated the effect of supplementing straw-based diets with different levels of DDGS on the growth performance and economic viability of growing ram lambs. A total of 24 ram lambs (16.

Validation of the Cognitive Assessment Instrument for Obsessions and Compulsions (CAIOC-13) in an Indian Sample.

Background: Brief self-report measures of cognition are advantageous for flagging significant cognitive dysfunction without extensive neuropsychological assessments. The Cognitive Assessment Instrument for Obsessions and Compulsions (CAIOC-13) is a recently developed self-report that assesses everyday cognitive dysfunction in obsessive-compulsive disorder (OCD), for example, difficulties with reading, slowness, and decision-making. This study was undertaken to validate the CAIOC-13 in an Indian sample of OCD.

Emerging insights into epigenetics and hematopoietic stem cell trafficking in age-related hematological malignancies.

Background: Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. Aging, diabetes, and obesity are significant contributors to BM niche damage, which can alter hematopoiesis and lead to the development of clonal hematopoiesis of intermediate potential (CHIP). Genetic/epigenetic alterations during aging could influence BM niche reorganization for hematopoiesis or clonal hematopoiesis.