Colloidal crystal engineering enables the precise construction of structures with remarkable properties. However, the flexible and synergistic regulation of multiple properties of colloidal crystals remains a significant challenge. Here, we inspire from Brazilian opals to self-assemble polymer nanoparticles in the gaps of a single-layer opal substrate to fabricate large-scale binary colloidal crystals (BCCs).
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Targeted degradation of membrane proteins represents an attractive strategy for eliminating pathogenesis-related proteins. Aptamer-based chimeras hold great promise as membrane protein degraders, however, their degradation efficacy is often hindered by the limited structural stability and the risk of off-target effects due to the non-covalent interaction with target proteins. We here report the first design of a covalent aptamer-based autophagosome-tethering chimera (CApTEC) for the enhanced autophagic degradation of cell-surface proteins, including transferrin receptor 1 (TfR1) and nucleolin (NCL).
View Article and Find Full Text PDFWe present a implementation method of light-sheet microscopy utilizing a highly miniaturized device that produces light-sheet illumination while immersed in the sample container. Our miniaturized plane illuminator (MPI) internally equips a two-axis beam-scanning mechanism based on a magnetostatically driven optical fiber cantilever. A light sheet is produced by fast scanning of the focused beam in an axis while the illumination plane can move in the other axis for positioning and 3D imaging.
View Article and Find Full Text PDFThe utilization of low-dimensional perovskites (LDPs) as interlayers on three-dimensional (3D) perovskites has been regarded as an efficient strategy to enhance the performance of perovskite solar cells. Yet, the formation mechanism of LDPs and their impacts on the device performance remain elusive. Herein, we use dimensional engineering to facilitate the controllable growth of 1D and 2D structures on 3D perovskites.
View Article and Find Full Text PDFAtomically precise nanoclusters (NCs) can serve as an excellent platform for a comprehensive understanding of structure-property relationships. Herein, three structurally similar Cu NCs (Cu-1, Cu-2 and Cu-3) have been prepared for the photocatalytic phenylacetylene self-coupling reaction. It was found that Cu-1 NC achieved the highest turnover number (TON) of 524.
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