Publications by authors named "Y P M Goekoop-Ruiterman"
Background: Undifferentiated arthritis (UA) is a term used to describe patients with inflammatory arthritis that has not differentiated into a specific rheumatic disease. UA may be a pre-stage of rheumatoid arthritis (RA) or another inflammatory disease or remain undifferentiated, but a substantial proportion of patients may also achieve spontaneous remission. As UA may be an early presentation of RA, rheumatologists often start methotrexate (or another csDMARD) as early as possible.
View Article and Find Full Text PDFObjectives: The widespread adoption of wearables, for example, smartphones and smartwatches in the daily lives of the general population, allows passive monitoring of physiological and behavioural data in the real world. This qualitative study explores the perspective of psoriatic arthritis (PsA) patients towards these so-called digital biomarkers (dBMs).
Methods: As part of a Design Thinking approach, six focus groups were conducted involving 27 PsA patients.
PERFECTRA: a pragmatic, multicentre, real-life study comparing treat-to-target strategies with baricitinib versus TNF inhibitors in patients with active rheumatoid arthritis after failure on csDMARDs.
RMD Open
May 2024
Article Synopsis
- The study compares the effectiveness of baricitinib and TNF-inhibitors (TNFi) in treating rheumatoid arthritis (RA) patients who did not respond to conventional treatments.
- A total of 199 patients were randomized, showing baricitinib to be both non-inferior and superior in achieving meaningful clinical responses at 12 weeks, with a higher percentage of patients reaching specified disease activity targets compared to TNFi.
- The results suggest that baricitinib may be a more effective initial treatment option than TNFi for RA patients who have failed previous therapies, based on the outcomes measured over 48 weeks.
Objective: Persistent articular inflammation in psoriatic arthritis (PsA) is associated with radiographic damage. Despite advances in diagnosis and therapy, radiographic structural damage remains prevalent in PsA. To elucidate this topic, we studied which baseline clinical characteristics determine radiographic progression.
View Article and Find Full Text PDFObjectives: To study long-term (up to 20-year) mortality of two treat-to-target trial cohorts in undifferentiated arthritis (UA) and early rheumatoid arthritis (RA).
Methods: The BeSt (BehandelStrategieën) study (n=508, early RA) was performed between 2000 and 2012. For 10 years, patients were treated-to-target disease activity score (DAS)≤2.