Publications by authors named "Y P Hecker"
Bovine abortions, often caused by infectious agents like Neospora caninum, inflict substantial economic losses. Studying host-pathogen interactions in pregnant cows is challenging, and existing cell cultures lack the intricate complexity of real tissues. To bridge the gap between in vitro and in vivo models, we explored the use of cryopreserved bovine placental explants.
View Article and Find Full Text PDFNeosporosis is the major infectious cause of abortion and reproductive losses in cattle worldwide; however, there are no available vaccines or drugs to control this disease. Recently, a dual (positive and negative) DIVA-like (Differentiation of Infected from Vaccinated Animals) vaccine was evaluated in a pregnant mouse model of neosporosis, showing promising immunogenic and protective results. The current report aimed to study the safety, the dose-dependent immunogenicity and the dual DIVA-like character of a recombinant subunit vaccine composed of the major surface antigen from Neospora caninum (rNcSAG1) and the carrier/adjuvant Heat shock protein 81.
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- The study investigated the presence of Sarcocystis species in rodents from Argentina, discovering that 8.7% of synanthropic and wild rodents showed positive signs of infection through histopathology.
- Four distinct 18S rRNA sequence groups were identified in several rodent species, with some sequences closely resembling S. dispersa and others showing low similarity to various Sarcocystis spp.
- The research marks the first molecular identification of Sarcocystis spp. in naturally infected rodents from the Cricetidae and Muridae families in South America, suggesting potential raptor or snake hosts for these parasites.
Article Synopsis
- Congenital toxoplasmosis is a significant issue in both humans and animals, causing abortion and fetal abnormalities.
- The CDPK1 inhibitor BKI-1748 demonstrated safety in humans and effectiveness against Toxoplasma gondii in lab studies and mouse models.
- In sheep infected during pregnancy, BKI-1748 treatment began 48 hours post-infection successfully prevented abortion and congenital infection, with treated sheep showing minimal symptoms compared to untreated ones.
The aim of the present systematic review and meta-analysis was to identify the main infectious agents related to bovine abortion worldwide in the period between 2000 and 2022. First, we investigated the global prevalence of infectious agents related to bovine abortion. For this analysis, only 27 articles detected of a wide panel of agents were included.
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