Full thickness abdominal wall defect in growing rats as a model for congenital diaphragmatic hernia prosthetic repair.

Background: Large congenital diaphragmatic hernia may require prosthetic correction. Acellular collagen matrices were introduced to avoid complications owing to the use of synthetic patches. We tested 3 different ACM for reconstruction of an abdominal wall defect in an animal model that mimics the fast growth during infancy.

Calculation of membrane tension in selected sections of the pelvic floor.

Introduction And Hypothesis: A mathematical model to estimate membrane tensions (Mt) at the urogenital hiatus and midpelvis in patients with and without prolapse is proposed. For that purpose the complex structures of the pelvic floor were simplified and, based on assumptions concerning geometry and loading conditions, Laplace's law was used to calculate Mt. The pelvic cavity is represented by an ellipsoid in which the midpelvic and hiatal sections are described by an ellipse.

A comparative study on culture conditions and routine expansion of amniotic fluid-derived mesenchymal progenitor cells.

Background: Amniotic fluid (AF) cell populations will be applied in perinatology. We aimed to test the feasibility of large-scale cell expansion.

Study Methods: We determined the best out of three published expansion protocols for mesenchymal progenitors (AF samples, n = 4) in terms of self-renewal ability.

Combined biaxial and uniaxial mechanical characterization of prosthetic meshes in a rabbit model.

The present experimental study is aimed at a combined uniaxial and biaxial mechanical characterization of the deformation behavior of two types of prosthetic meshes, SPMM (heavy-weight) and Gynemesh M (light-weight, partly absorbable), after integration in the host tissue. Explants from a full-thickness-abdominal-wall-defect-rabbit-model were tested in the two loading conditions. Corresponding protocols and data analysis procedures for biaxial inflation tests and uniaxial tensile tests were developed.

One-year outcome of biological and synthetic bioabsorbable meshes for augmentation of large abdominal wall defects in a rabbit model.

Background: Long-term efficacy of biological and synthetic bioabsorbable meshes for large hernia repair is currently unclear. This rabbit study is aimed at investigating 1-y outcome of biological and synthetic bioabsorbable meshes for augmentation of large abdominal wall defects.

Materials And Methods: In 46 rabbits, an 11 × 4 cm, full-thickness abdominal wall defect was repaired primarily, or with cross-linked (Permacol, Collamend) or non-cross-linked (Surgisis 4-ply, Surgisis Biodesign) biological, synthetic bioabsorbable (GORE BIO-A Tissue Reinforcement [TR], TIGR Matrix Surgical Mesh [MSM]), or polypropylene (Bard Mesh) meshes, using the underlay augmentation technique.