Publications by authors named "Y Owada"
Article Synopsis
- FABP7 is a protein found in the brain that may help transport cannabinoids like THC, but its role in the endocannabinoid system is not fully understood.
- In a study using mice lacking FABP7, researchers measured THC and its metabolite 11-OH-THC levels after THC inhalation, finding that females with FABP7 deletion had lower levels of 11-OH-THC compared to those with the protein.
- The study also revealed that FABP7 influences endocannabinoid levels, showing females with FABP7 deletion had decreased levels of anandamide and increased levels of 2-AG, indicating a sex-specific role in THC metabolism and endocannabinoid regulation.
Fatty acid binding protein 7 (FABP7) is a multifunctional chaperone involved in lipid metabolism and signaling. It is primarily expressed in astrocytes and neural stem cells (NSCs), as well as their derived malignant glioma cells within the central nervous system. Despite growing evidence for FABP7's tumor-intrinsic onco-metabolic functions, its mechanistic role in regulating the brain tumor immune microenvironment (TIME) and its impact on prognosis at the molecular level remain incompletely understood.
View Article and Find Full Text PDFFatty acid-binding protein 7 (FABP7) aids in the intracellular transport of endogenous cannabinoids and is involved in regulating the stress response system. This study examined the role of FABP7 in chronic stress exposure through the binding of CB1 receptors. Adult male FABP7 and FABP7 mice were treated with the unpredictable chronic mild stress (UCMS) procedure.
View Article and Find Full Text PDFObjective: This study aimed to understand the effectiveness of regular care in reducing the incidence of severe peristomal skin disorders, as well as to identify their risk factors.
Summary Background Data: Peristomal skin disorders occur frequently in outpatient settings and require appropriate intervention. It remains, however, to be demonstrated when the need to follow up these patients decreases and whether assessing severity of peristomal skin disorders is useful.