Publications by authors named "Y Ortega"
Background: Intracavernosal injection therapy is often used as second-line therapy for erectile dysfunction associated with radical prostatectomy when therapy with phosphodiesterase-5 inhibitors has failed, but prostaglandin E1-containing vasoactive agents are associated with penile pain in some men.
Objectives: To define the incidence of pain with prostaglandin E1-containing intracavernosal injection mixtures for erectile dysfunction associated with radical prostatectomy when therapy with phosphodiesterase-5 inhibitors has failed, and whether pain was a predictor of erectile function recovery.
Materials And Methods: Men who underwent radical prostatectomy and were commenced on intracavernosal injection within 12 months of radical prostatectomy were included.
Article Synopsis
- Common neuropathologies linked to dementia include Alzheimer's disease neuropathologic change (ADNC) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC), with biofluid proteomics playing a key role in understanding their biology.
- A study at the University of Kentucky assessed cerebrospinal fluid (CSF) from 29 older adults, categorizing them into LATE-NC+ (9 cases with advanced LATE-NC) and LATE-NC- (20 cases without it).
- Out of nearly 950 proteins identified, only 4 showed significant differences between the two groups, with RBP4 being notably higher in LATE-NC+ cases, suggesting a
Article Synopsis
- The study aimed to establish the diagnostic accuracy of sarcopenia in older adults (≥60 years) using muscle mass and functional measurements, and propose new cut-off points for diagnosis.
- A cross-sectional analysis included 50 participants, 38 with probable sarcopenia and 12 without, assessing parameters like muscle quality using bioimpedance analysis, isokinetic measures, and ultrasound.
- Key findings identified specific cut-off values for phase angle and strength measures (e.g., peak torque, mean power) that showed high diagnostic accuracy for sarcopenia in both men and women, suggesting these could help confirm diagnoses, but further research is necessary.
Background: Intracavernosal injection therapy (ICI) is a well-established therapeutic strategy for men with erectile dysfunction. Complications are often related to patient error when performong ICI.
Aim: The objective of this study was to examine patient errors in an established patient training program for performing ICI and identify factors that could predict major errors.
Multiple sclerosis, and its murine model experimental autoimmune encephalomyelitis (EAE), is a neurodegenerative autoimmune disease of the CNS characterized by T cell influx and demyelination. Similar to other autoimmune diseases, therapies can alleviate symptoms but often come with side effects, necessitating the exploration of new treatments. We recently demonstrated that the Cullin-RING E3 ubiquitin ligase 4b (CRL4b) aided in maintaining genome stability in proliferating T cells.
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