Publications by authors named "Y Onoe"
IKAROS and CTLA4 deficiencies are inborn errors of immunity and show similar clinical phenotypes, including hypogammaglobulinemia and autoimmune diseases (ADs). However, the differences in clinical features and pathogenesis of these are not fully understood. Therefore, we performed systematic literature reviews for IKAROS and CTLA4 deficiencies.
View Article and Find Full Text PDFThe aim of this study was to identify pharmacogenomic biomarkers to predict tegafur-uracil (UFT)-induced liver dysfunction. A total of 68 patients, who were administered UFT, were evaluated using a two-step pharmacogenomics analysis. The first screening revealed the association between five SNPs and UFT-induced hepatic dysfunction.
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- * A survey of 296 young Japanese women revealed a positive correlation between VitD intake and serum 25(OH)D levels, indicating that higher VitD consumption improves vitamin D status.
- * The study found that a VitD intake of at least 11.6 μg/day is necessary to maintain serum 25(OH)D levels above 20 ng/mL for bone health, suggesting that the current recommended allowance of 5.5 μg/day may be inadequate.
Background: We previously reported that biofilms and innate immunity contribute to the pathogenesis of Kawasaki disease. Therefore, we aimed to assess the efficacy of clarithromycin, an antibiofilm agent, in patients with Kawasaki disease.
Methods And Results: We conducted an open-label, multicenter, randomized, phase 2 trial at 8 hospitals in Japan.
Unlabelled: This study investigated the relationships between intakes of polyunsaturated fatty acids, omega-3 fatty acids, and omega-6 fatty acids and bone mineral density in Japanese women aged 19 to 25 years. Intakes of omega-3 fatty acids (n-3) were positively associated with peak bone mass at the hip.
Introduction: Lifestyle factors such as physical activity and nutrition intake are known to optimize the peak bone mass (PBM).