Publications by authors named "Y Onoda"
Article Synopsis
- Recent clinical trials indicate that patients with metastatic castration-sensitive prostate cancer exhibit varying overall survival rates based on tumor burden and visceral metastasis, with some low-burden patients still facing poor survival.
- This study examined data from 261 newly diagnosed patients to assess time to castration resistance as a potential prognostic factor, alongside other variables like age and metastasis type.
- Results showed that a shorter time to castration resistance significantly correlated with reduced overall survival, highlighting the persistence of androgen receptor signaling even post-castration resistance and suggesting its potential as a biomarker regardless of tumor burden.
Article Synopsis
- * Out of 451 patients over 65 years with cervical fractures, 69% had mid-cervical injuries while 31% had lower-cervical injuries, with lower-cervical injuries being linked to more high-energy trauma cases.
- * Although lower-cervical injuries resulted in fewer muscle weaknesses compared to mid-cervical injuries, many patients still experienced neurological deficits and similar overall complication rates after treatment, such as respiratory issues but no significant differences in mortality or mobility outcomes.
Introduction: Preoperative estimations of blood loss are important when planning surgery for cervical spine injuries in older adults. The association between ankylosis and blood loss in perioperative management is of particular interest. This multicenter database review aimed to evaluate the impact of ankylosis on surgical blood loss volume in elderly patients with cervical spine injury.
View Article and Find Full Text PDFArticle Synopsis
- Dysphagia, a serious swallowing disorder, affects older adults post-spinal cord injury, particularly those with cervical injuries, though its risk factors are not well understood.
- A study involving 707 patients aged 65 and older identified male sex, low nutritional status (GNRI <92), dementia, fractures, complete paralysis, anterior surgery, and tracheostomy as significant risk factors for dysphagia.
- The findings suggest that a low geriatric nutritional risk index (GNRI) is a key indicator of dysphagia risk, implying that nutritional health is critical for recovery in elderly patients with cervical spinal injuries.
Article Synopsis
- - Researchers isolated a new lectin, named hRTL, from a marine sponge, which belongs to the galectin family and shows high similarity to another galectin called CCL.
- - hRTL is a tetramer composed of 141 amino acids and features a unique 23 amino acid signal peptide that gets cleaved after translation, differing from most galectins which usually have acetylated modifications.
- - The hRTL lectin binds strongly to specific glycan structures and has been shown to induce cytotoxic effects in colorectal cancer cells expressing certain antigens, suggesting potential therapeutic implications.