Publications by authors named "Y Oji"
Wilms' tumor protein 1 (WT1)-targeted immunotherapy has been used in patients with leukemia and solid tumors. However, the spontaneous WT1-specific immune response before WT1 peptide vaccination in patients with WT1-expressing tumors (PTs) remains unclear. Therefore, we investigated whether WT1-specific cytotoxic CD8 T-lymphocytes (CTLs) are clonally expanded in the peripheral blood outside of tumor sites.
View Article and Find Full Text PDFExercise Habits in People with Parkinson's: A Multinational Survey.
Mov Disord Clin Pract
November 2024
Article Synopsis
- Exercise improves physical function, cognition, and quality of life for people with Parkinson's (PwP), but participation levels vary among individuals.
- A survey of 2,976 PwP found that 40.6% exercised regularly, with higher activity linked to group workouts, weightlifting, and use of muscle-building equipment.
- Factors promoting exercise included education level, receiving advice from doctors, being diagnosed at a younger age, while issues like falls and bothersome symptoms deterred exercise participation.
Antibodies serve as crucial indicators of the immune system in clinical tests. In therapeutic cancer vaccines, IgG antibodies against target antigens are vital for immune monitoring. Additionally, assessing baseline antigen-specific immune responses before cancer vaccine administration is possible by measuring IgM and IgG antibodies against the target antigen.
View Article and Find Full Text PDFBackground: Chronic constipation is a common digestive complication of Parkinson's disease (PD).
Objectives: To verify the usefulness of elobixibat, an ileal bile acid transporter inhibitor, for chronic constipation in PD.
Methods: This double-blind, placebo-controlled study consisted of a 2-week observation/washout period and a 4-week treatment period.
Objectives: To investigate the construct validity of the Trunk Impairment Scale (TIS), which was developed to assess trunk impairment in patients with stroke, in patients with Parkinson's disease (PD).
Design: This retrospective, cross-sectional study enrolled consecutive PD inpatients. Correlation analysis was performed to clarify whether the TIS assessment was related to other balance functions, lower extremity muscle strength, or walking ability.