Publications by authors named "Y Nunez"
Objective: This study investigated the genetic and epigenetic mechanisms underlying the comorbidity patterns of five substance dependence diagnoses (SDs; alcohol, AD; cannabis, CaD; cocaine, CoD; opioid, OD; tobacco, TD).
Methods: A latent class analysis (LCA) was performed on 31,197 individuals (average age 42±11 years; 49% females) from six cohorts to identify comorbid DSM-IV SD patterns. In subsets of this sample, we tested SD-latent classes with respect to polygenic burden of psychiatric and behavioral traits and epigenome-wide changes in three population groups.
Article Synopsis
- - Opioid dependence (OD) is a growing health crisis in the U.S., with roughly 50% heritability and numerous common genetic risk variants identified, yet rare variants remain unexplored.
- - An analysis of whole-exome sequencing data from a large Yale-Penn cohort (2,100 participants) found a novel low-frequency variant linked to OD, as well as various suggestive associations across different ancestry groups.
- - The study highlights key genes associated with OD, primarily due to rare variants, which could inform future research and help in developing targeted treatments.
Article Synopsis
- Antioxidant supplementation, particularly with high levels of vitamin E and hydroxytyrosol, during key periods of pregnancy may enhance the early viability and growth of piglets.
- A study analyzed the effects of these diets on the adipose tissue of weaned piglets, revealing significant changes in gene expression related to metabolism and inflammation.
- While vitamin E alone promoted beneficial metabolic functions, the combined antioxidant approach produced results resembling the control diet, raising questions about its effectiveness.
Article Synopsis
- A study found a strong link between antisocial personality disorder (ASPD) and various substance use disorders (SUD), specifically alcohol, cannabis, and tobacco use disorders.
- The association was particularly significant for the "hazardous use" criteria across all SUDs, suggesting that individuals with ASPD often engage in riskier substance use.
- Notably, ASPD was related to a lower likelihood of attempting to quit cocaine, indicating that those with ASPD may struggle more with cessation efforts for certain substances.
Identifying neurofunctional domains across substance use disorders.
Am J Drug Alcohol Abuse
July 2024
Substance use disorders (SUDs) are heterogeneous across multiple functional domains. Various frameworks posit that domains (e.g.
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