Publications by authors named "Y Nishijima"
Article Synopsis
- Type 2 diabetes mellitus (T2DM) leads to smaller pial vessels and lower blood flow velocity before and after a stroke, contributing to poor recovery outcomes.
- After a stroke, T2DM mice showed persistent deficits in blood flow and increased leukocyte adhesion to blood vessel walls, highlighting chronic inflammation's role in complicating recovery.
- The study used two-photon microscopy to analyze blood flow dynamics, vessel remodeling, and inflammation in the brain, suggesting that T2DM-induced changes worsen stroke effects.
Nuclear laminar or inner nuclear membrane proteins, including lamin A, B1, and B2 and emerin, are involved in maintaining nuclear morphology. However, their expression patterns vary among tumors and remain incompletely understood. Endometrioid carcinoma (EC) exhibits mild nuclear atypia, although the underlying reasons have not been thoroughly explored.
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- No prior reports have compared section thickness (ST) between sliding microtomes (SM) and rotary microtomes (RM), leading to a study using two cooling conditions: ice pack (IP) and continuous cooling device (CCD).
- Results showed that while ST was greater for SM under IP conditions, both microtomes had identical ST when using the CCD condition; thus, CCD was selected for further research.
- The study found a significant difference in ST between tissue surfaces and paraffin surfaces in fish sausage blocks, but no difference in human kidney blocks, highlighting the importance of consistent ST and cooling methods for accurate quantitative analysis.
Article Synopsis
- The study focused on comparing the effectiveness of Pipet Curet cytology (PCC) and Pipet Curet biopsy (PCB) for diagnosing endometrial endometrioid carcinoma (EEC) in 77 patients, categorized based on the Federation of Gynecology and Obstetrics (FIGO) grades.
- Results showed that the diagnostic sensitivity was significantly higher for advanced G2/3 EEC cases than for G1 EECs across all methods, indicating that more aggressive cancer types yield easier detection.
- The combination of both PCC and PCB improved diagnostic accuracy, suggesting that using these methods together can reduce false negatives and enhance EEC diagnosis.
Article Synopsis
- Emerin and lamins play a role in shaping the nucleus and may influence cell differentiation, particularly in lung adenocarcinoma.
- A study of 82 lung adenocarcinoma cases found that the expression levels of lamin A, B1, B2, and emerin correlated with nuclear characteristics and differentiation grades, with lower levels in poorly differentiated tumors (G3).
- Specifically, acinar adenocarcinomas with cribriform patterns showed significantly reduced expression of these proteins compared to other histological subtypes, indicating a potential link between protein levels and tumor aggressiveness.