Publications by authors named "Y Nishihata"
The dorsolateral prefrontal cortex (DLPFC) plays a crucial role in primate cognition, integrating multimodal information to generate top-down signals for cognitive control. During cognitive tasks, the DLPFC displays activity patterns of exceptional complexity and duration not observed in other cortical areas or species. These activity patterns are likely associated with the unique physiological and morphological properties of primate DLPFC pyramidal neurons (PNs).
View Article and Find Full Text PDFBackground: The optimal timing for the initiation of oral beta-blockers after acute myocardial infarction (MI) remains unclear within the context of current primary percutaneous coronary intervention (PCI) practice.
Methods: This retrospective cohort study included 412 consecutive patients admitted with a diagnosis of acute MI between January 2007 and August 2016 who underwent successful primary PCI and were given oral carvedilol during hospitalization. Early and late carvedilol groups were based on initiation within the first 24 h or after.
Article Synopsis
- ST-segment elevation myocardial infarction complicated by cardiogenic shock (STEMI-CS) has high mortality rates, especially for patients admitted during off-hours, known as the "off-hours effect."
- This study analyzed registry data of 1,207 patients treated with Impella, revealing that 42.1% of off-hours admissions resulted in death compared to 30.3% during on-hours.
- The research concluded that off-hours admissions were linked to a 60% increased risk of 30-day mortality, emphasizing the need for improved cardiovascular care and timely treatment during off-hours.
Unlabelled: In schizophrenia, layer 3 pyramidal neurons (L3PNs) in the dorsolateral prefrontal cortex (DLPFC) are thought to receive fewer excitatory synaptic inputs and to have lower expression levels of activity-dependent genes and of genes involved in mitochondrial energy production. In concert, these findings from previous studies suggest that DLPFC L3PNs are hypoactive in schizophrenia, disrupting the patterns of activity that are crucial for working memory, which is impaired in the illness. However, whether lower PN activity produces alterations in inhibitory and/or excitatory synaptic strength has not been tested in the primate DLPFC.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how social isolation during critical development stages affects behavior and neuronal activity, focusing on the expression of specific proteins in the prefrontal cortex (PFC) of mice.
- Researchers compared socially isolated mice with those kept in groups, observing changes in neuronal firing patterns and social behavior.
- Results indicated that isolated mice struggled with social memory, and decreased NARP expression was found in humans with autism compared to typically developing individuals, suggesting a link between social isolation and behavioral outcomes.