Publications by authors named "Y Niibe"
Background/aim: Data on metastasis-directed radiotherapy (MDRT) are limited, particularly regarding its association with the prostate-specific antigen (PSA) doubling time (PSADT). The present study evaluated the oncological outcomes of MDRT on the basis of the PSADT in oligo-recurrent prostate cancer patients.
Patients And Methods: We retrospectively reviewed clinical data of 35 MDRTs for 29 patients at the Kitasato University Hospital, targeting oligometastatic prostate cancer developed after radical treatment for non-metastatic prostate cancer.
Article Synopsis
- The study examines how diafiltration, adsorption, and hematocrit levels affect the clearance of ganciclovir (GCV) during continuous hemodiafiltration (CHDF) using various membrane types.
- Results indicate that diafiltration is the primary factor influencing GCV clearance, while adsorption has minimal impact.
- Hematocrit levels do not significantly alter the clearance relationship between plasma and blood GCV concentrations, suggesting that clearance can be estimated from effluent flow rates.
Article Synopsis
- Patients with neuroimmunological disorders often require glucocorticoids, which can lead to osteoporosis, but little research has been done on managing this complication in these patients.
- A study compared the effectiveness of two treatments, denosumab and bisphosphonates, on bone mineral density (BMD) in 57 such patients receiving corticosteroids.
- Results showed that denosumab significantly increased lumbar spine and hip BMD compared to bisphosphonates over a follow-up period of up to 6 years, making it the more effective option for these patients.
One-third of renal cell carcinomas (RCCs) without metastases develop metastatic disease after extirpative surgery for the primary tumors. The majority of metastatic RCC cases, along with treated primary lesions, involve limited lesions termed "oligo-recurrent" disease. The role of metastasis-directed therapy (MDT), including stereotactic body radiation therapy (SBRT) and metastasectomy, in the treatment of oligo-recurrent RCC has evolved.
View Article and Find Full Text PDFObjectives: The pharmacokinetics of vancomycin and meropenem in patients treated with continuous online hemodiafiltration (OL-HDF) are not well understood.
Case: We evaluated dialytic clearance and serum concentrations of vancomycin and meropenem by OL-HDF in a critically ill patient with soft tissue infection. The mean clearance of OL-HDF and mean serum concentrations during continuous OL-HDF were 155.