Role of caffeine in slowing progression of myopia: 1-year results from a prospective, longitudinal clinical trial.

Purpose: To determine the role of topical caffeine in slowing progression of myopia, both as a standalone treatment and in combination with atropine.

Methods: In a prospective, randomized, dispensing clinical trial, 96 children with myopia, aged 6-13 years, spherical equivalent (SE) from -0.50 diopters (D) to -6.

The effects of paced breathing on psychological distress vulnerability and heart rate variability in adults sustaining traumatic injury.

Background: Traumatic physical injuries can lead to psychological distress and increased risk of psychiatric disorders, often reflected in dysregulated autonomic responses measurable through heart rate variability (HRV). Slow-paced breathing has shown potential in enhancing HRV, but its effectiveness in injured survivors remains unexplored. This study investigates the effect of slow-paced breathing on HRV among injured survivors compared to non-injured individuals and explores the influence of psychological distress and spontaneous respiratory rate on this effect.

Truncated recombinant Jagged1 fused with human IgG1 Fc activates Notch target genes in human periodontal ligament cells.

Objective: Jagged1, a Notch ligand, is essential for osteogenic differentiation in human periodontal ligament cells (hPDLs) by interacting with Notch2 to induce osteogenic markers, alkaline phosphatase activity, and mineral deposition. However, its large size hampers absorption and distribution of biomaterials. This study aimed to identify the critical region of Jagged1 necessary for its interaction with Notch2 to create a truncated version that retains osteogenic activity but with improved delivery characteristics.

Clustering for mitigating subject variability in driving fatigue classification using electroencephalography source-space functional connectivity features.

While Electroencephalography (EEG)-based driver fatigue state classification models have demonstrated effectiveness, their real-world application remains uncertain. The substantial variability in EEG signals among individuals poses a challenge in developing a universal model, often necessitating retraining with the introduction of new subjects. However, obtaining sufficient data for retraining, especially fatigue data for new subjects, is impractical in real-world settings.