Publications by authors named "Y Nakatsu"

Article Synopsis
  • The study assessed the effectiveness of the spring-and-loop with clip (S-O clip) in gastric endoscopic submucosal dissection (ESD) by comparing outcomes in 290 patients with early gastric neoplasms who did and did not use the clip.
  • Results indicated that patients using the S-O clip had significantly shorter procedure times (44.4 minutes vs. 61.1 minutes) and higher complete resection rates (97.9% vs. 92.6%) compared to those without the clip.
  • The findings suggest that the S-O clip enhances efficiency and outcomes in ESD, particularly benefiting less experienced endoscopists during procedures.
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Annotating genomic sequence alterations is sometimes a difficult decision, particularly in missense variants with uncertain pathogenic significance and also in those presumed as germline pathogenic variants. We here suggest that mutation spectrum may also be useful for judging them. From the public databases, 982 BRCA1/1861 BRCA2 germline missense variants and 294 BRCA1/420 BRCA2 somatic missense variants were obtained.

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Mutations in the Trk-fused gene (TFG) cause hereditary motor and sensory neuropathy with proximal dominant involvement, which reportedly has high co-incidences with diabetes and dyslipidemia, suggesting critical roles of the TFG in metabolism as well. We found that TFG expression levels in white adipose tissues (WATs) were elevated in both genetically and diet-induced obese mice and that TFG deletion in preadipocytes from the stromal vascular fraction (SVF) markedly inhibited adipogenesis. To investigate its role in vivo, we generated tamoxifen-inducible adipocyte-specific TFG knockout (AiTFG KO) mice.

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